Ong Song, Mannon Roslyn B
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA; Division of Transplantation, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, USA.
Transplant Rev (Orlando). 2015 Apr;29(2):60-7. doi: 10.1016/j.trre.2014.12.003. Epub 2014 Dec 10.
Acute dysfunction of a kidney transplant can be the result of many different etiologies and an allograft biopsy is frequently necessary to diagnose acute rejection. This invasive procedure, while generally safe, is time consuming, costly and inconvenient. We summarize recent advances in genomic and proteomic techniques using peripheral blood and urine for the diagnosis of acute rejection. While much progress has been made, validation of these new molecular tests in the clinical setting is still required.
肾移植急性功能障碍可能由多种不同病因引起，通常需要进行移植肾活检来诊断急性排斥反应。这种侵入性操作虽然总体安全，但耗时、费用高且不方便。我们总结了利用外周血和尿液进行急性排斥反应诊断的基因组学和蛋白质组学技术的最新进展。尽管已经取得了很大进展，但仍需要在临床环境中对这些新的分子检测进行验证。
