TLR2和TLR4基因多态性对土耳其冠心病患者的影响。
The effect of genetic polymorphisms of TLR2 and TLR4 in Turkish patients with coronary artery disease.
作者信息
Guven Mehmet, Ismailoglu Ziya, Batar Bahadir, Unal Selin, Onaran Ilhan, Karadag Bilgehan, Ongen Zeki
机构信息
Istanbul University, Cerrahpasa Medical Faculty, Department of Medical Biology, Istanbul, Turkey.
Istanbul University, Cerrahpasa Medical Faculty, Department of Cardiology, Istanbul, Turkey.
出版信息
Gene. 2015 Mar 1;558(1):99-102. doi: 10.1016/j.gene.2014.12.047. Epub 2014 Dec 24.
Coronary artery disease (CAD), being a multifactorial disease process, has been suggested to be associated by the interaction of both environmental and genetic risk factors. Toll-like receptors (TLRs) are related to the receptors of the innate immune system which serves as the recognition of the conserved pathogen motifs and the activation of the signals that stimulate inflammatory genes. In this study, we investigated the relationship between the polymorphisms in the TLR2-Arg753Gly, TLR4-Asp299Gly and Thr399Ile gene and CAD. The study population consisted of 300 patients (149 men, 151 women) with angiographically documented CAD. The polymorphisms were genotyped by real time PCR. No association between TLR2-Arg677Trp or TLR4-Asp299Gly and -Thr399Ile gene polymorphisms and the presence or the severity of CAD was observed. On the other hand, the TLR2-Arg753Arg genotype seemed to have a protective effect against development of CAD (OR=0.17; 95% CI=0.04-0.83). Our findings suggest that TLR2-Arg753Gly polymorphism is associated with CAD susceptibility in Turkish patients.
冠状动脉疾病（CAD）是一种多因素疾病过程，有人认为它是由环境和遗传风险因素的相互作用引起的。Toll样受体（TLR）与先天免疫系统的受体有关，先天免疫系统负责识别保守的病原体基序并激活刺激炎症基因的信号。在本研究中，我们调查了TLR2-Arg753Gly、TLR4-Asp299Gly和Thr399Ile基因多态性与CAD之间的关系。研究人群包括300例经血管造影证实患有CAD的患者（149名男性，151名女性）。通过实时PCR对多态性进行基因分型。未观察到TLR2-Arg677Trp或TLR4-Asp299Gly和-Thr399Ile基因多态性与CAD的存在或严重程度之间存在关联。另一方面，TLR2-Arg753Arg基因型似乎对CAD的发展具有保护作用（OR=0.17；95%CI=0.04-0.83）。我们的研究结果表明，TLR2-Arg753Gly多态性与土耳其患者的CAD易感性有关。
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