对疑似患有非酒精性脂肪性肝病（NAFLD）且过度饮酒的南非黑人的心脏代谢状况进行比较。
A comparison of the cardiometabolic profile of black South Africans with suspected non-alcoholic fatty liver disease (NAFLD) and excessive alcohol use.
作者信息
Zatu Mandlenkosi Caswell, van Rooyen Johannes Marthinus, Loots Du Toit, Greeff Minrie, Schutte Aletta Elisabeth
机构信息
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, North West Province 2520, South Africa; Department of Physiology, University of Limpopo (Medunsa), Pretoria, Gauteng 0001, South Africa; Medical Research Council: Research Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North West University, South Africa.
Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, North West Province 2520, South Africa; Medical Research Council: Research Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North West University, South Africa.
出版信息
Alcohol. 2015 Mar;49(2):165-72. doi: 10.1016/j.alcohol.2014.11.002. Epub 2014 Dec 3.
Excessive alcohol use and non-alcoholic fatty liver disease (NAFLD) are putative cardiovascular disease risk factors. In order to ease the identification of these conditions on primary health care level, we aimed to determine and compare the demographic and cardiometabolic characteristics of excessive alcohol users and those with suspected NAFLD in black South Africans. In the Prospective Urban Rural Epidemiology study (North West Province, South Africa, N = 2021, collected in 2005) we selected 338 participants, namely: 1) alcohol users (N = 143) reporting 'yes' to alcohol intake, with high gamma-glutamyl transferase (GGT) ≥80 U/L and a percentage carbohydrate deficient transferrin (%CDT) ≥2%; 2) non-alcohol users (N = 127) self-reporting 'no' to alcohol intake with GGT ≤30 U/L and %CDT ≤2%; and 3) NAFLD group (N = 68) who were non-drinkers with GGT levels ≥60 U/L and %CDT ≤ 2%. The demographics indicated that the alcohol users were mostly men (73%) with a body mass index (BMI) of 19.8 (15.2-27.3) kg/m(2), 90% of which were smokers. Systolic blood pressure (SBP) of alcohol users significantly correlated with high-density lipoprotein cholesterol (HDL-C) (β = 0.24; p = 0.003) and waist circumference (WC) (β = 0.22; p = 0.006). Non-alcohol users were mostly women (84%) with a BMI of 26.0 (18.0-39.2) kg/m(2) and blood pressure in this group related positively with triglycerides. The NAFLD group were also mostly women (72%) with a comparatively larger WC (p < 0.001) and an adverse metabolic profile (total cholesterol: 5.55 ± 1.69 mmol/L; glycosylated hemoglobin: 6.03 (4.70-9.40) %). Diastolic blood pressure in the NAFLD group associated positively with WC (β = 0.27; p = 0.018). We therefore found disparate gender and cardiometabolic profiles of black South Africans with suspected NAFLD and excessive alcohol use. The described profiles may aid health care practitioners in low resource settings when using these crude screening measures of gender, obesity indices (and self-reported alcohol use) to identify individuals at risk.
过量饮酒和非酒精性脂肪性肝病（NAFLD）被认为是心血管疾病的危险因素。为了在初级卫生保健层面更轻松地识别这些病症，我们旨在确定并比较南非黑人中过量饮酒者和疑似患有NAFLD者的人口统计学特征及心脏代谢特征。在“城乡前瞻性流行病学研究”（南非西北省，2005年收集，N = 2021）中，我们选取了338名参与者，即：1）饮酒者（N = 143），报告有饮酒行为，且γ-谷氨酰转移酶（GGT）≥80 U/L，碳水化合物缺乏转铁蛋白百分比（%CDT）≥2%；2）不饮酒者（N = 127），自我报告无饮酒行为，GGT≤30 U/L且%CDT≤2%；3）NAFLD组（N = 68），为不饮酒者，GGT水平≥60 U/L且%CDT≤2%。人口统计学数据表明，饮酒者大多为男性（73%），体重指数（BMI）为19.8（15.2 - 27.3）kg/m²，其中90%为吸烟者。饮酒者的收缩压（SBP）与高密度脂蛋白胆固醇（HDL-C）（β = 0.24；p = 0.003）和腰围（WC）（β = 0.22；p = 0.006）显著相关。不饮酒者大多为女性（84%），BMI为26.0（18.0 - 39.2）kg/m²，该组血压与甘油三酯呈正相关。NAFLD组也大多为女性（72%），腰围相对较大（p < 0.001），且代谢状况不佳（总胆固醇：5.55±1.69 mmol/L；糖化血红蛋白：6.03（4.70 - 9.40）%）。NAFLD组的舒张压与WC呈正相关（β = 0.27；p = 0.018）。因此，我们发现疑似患有NAFLD和过量饮酒的南非黑人存在不同的性别及心脏代谢特征。当在资源匮乏地区使用这些关于性别、肥胖指数（以及自我报告的饮酒情况）的粗略筛查措施来识别高危个体时，所描述的这些特征可能会对医疗从业者有所帮助。
Zotero 插件