Malek Angela M, Barchowsky Aaron, Bowser Robert, Heiman-Patterson Terry, Lacomis David, Rana Sandeep, Talbott Evelyn O
Department of Public Health Sciences, College of Medicine, Medical University of South Carolina, Charleston, SC, 29425, USA.
Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, 15219, USA.
Environ Pollut. 2015 Feb;197:181-186. doi: 10.1016/j.envpol.2014.12.010. Epub 2014 Dec 23.
Amyotrophic lateral sclerosis (ALS) is a serious and rapidly fatal neurodegenerative disorder with an annual incidence of 1-2.6/100,000 persons. Few known risk factors exist although gene-environment interaction is suspected. We investigated the relationship between suspected neurotoxicant hazardous air pollutants (HAPs) exposure and ALS.
A case-control study involving sporadic ALS cases (n = 51) and matched controls (n = 51) was conducted from 2008 to 2011. Geocoded residential addresses were linked to U.S. EPA NATA data (1999, 2002, and 2005) by census tract. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression.
Residential exposure to aromatic solvents significantly elevated the risk of ALS among cases compared to controls in 2002 (OR = 5.03, 95% CI: 1.29, 19.53) and 1999 (OR = 4.27, 95% CI: 1.09, 16.79) following adjustment for education, smoking, and other exposure groups. Metals, pesticides, and other HAPs were not associated with ALS.
A potential relationship is suggested between residential ambient air aromatic solvent exposure and risk of ALS in this study.
肌萎缩侧索硬化症（ALS）是一种严重且迅速致命的神经退行性疾病，年发病率为1-2.6/100,000人。尽管怀疑存在基因-环境相互作用，但已知的风险因素很少。我们研究了疑似神经毒性有害空气污染物（HAPs）暴露与ALS之间的关系。
2008年至2011年进行了一项病例对照研究，涉及散发性ALS病例（n = 51）和匹配的对照（n = 51）。通过普查区将地理编码的居住地址与美国环境保护局（EPA）的国家空气有毒物质评估（NATA）数据（1999年、2002年和2005年）相关联。使用条件逻辑回归计算比值比（OR）和95%置信区间（CI）。
在对教育程度、吸烟情况和其他暴露组进行调整后，2002年（OR = 5.03，95% CI：1.29，19.53）和1999年（OR = 4.27，95% CI：1.09，16.79），病例组中居住环境暴露于芳香族溶剂的人群患ALS的风险与对照组相比显著升高。金属、农药和其他HAPs与ALS无关。
本研究表明居住环境中芳香族溶剂暴露与ALS风险之间可能存在关联。
