Morrissette Debbi Ann, Stahl Stephen M
1Neuroscience Education Institute,Carlsbad,CA,USA.
CNS Spectr. 2014 Dec;19 Suppl 1:57-67; quiz 54-7, 68. doi: 10.1017/S1092852914000613.
Discuss the theory of modulation of receptor activity or the blockade of the reuptake of multiple neurotransmitter systems for the future treatment of MDD. Major depressive disorder (MDD) is a serious and often crippling psychiatric illness with a high risk of relapse and treatment resistance. In this article, we discuss the role of the serotonergic system in MDD including our current understanding of how various serotonin (5HT) receptors modulate monoamine neurotransmission and behavior. We also discuss how pharmacologic interventions, including novel and existing antidepressants and atypical antipsychotics, may be utilized to adjust serotonergic neurotransmission and provide more effective treatments for patients with MDD.
讨论受体活性调节理论或多种神经递质系统再摄取阻断在重度抑郁症未来治疗中的应用。重度抑郁症（MDD）是一种严重且常常使人致残的精神疾病，复发风险高且存在治疗抵抗。在本文中，我们讨论了血清素能系统在MDD中的作用，包括我们目前对各种血清素（5HT）受体如何调节单胺能神经传递和行为的理解。我们还讨论了如何利用药物干预措施，包括新型和现有的抗抑郁药及非典型抗精神病药，来调节血清素能神经传递，并为MDD患者提供更有效的治疗。
