Panghea P, Anastasatu C
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1989 Jan-Mar;38(1):31-8.
This work proposes to analyse the quality of the failure risks in the case of a short duration treatment applied in operational conditions on the territory of Constanţa County as a premise for the application of a method of mathematical analysis on computer in view of predicting the failure cases. There were studied 262 eligible cases out of 290, which represent the total of the patients newly registered with pulmonary tuberculosis in 1982, on the territory of Constanţa County and who were kept an eye upon for 3 years after finishing the treatment. There resulted 58 (22.1%) recurrencies, failures or corrected in course intratherapeutic positive reactions, on which were analysed 25 possible failure factors. The most representative have proved to be the organizational factors among which irregular treatment (67.2%) of the failure cases, a defective mobilizing to treatment, technical factors: late negativation of sputum (over 4-5 months from starting the treatment), and among the factors depending on the patients--noncooperation occurred in 60.33% of the failure cases. If the final frequency of failures on the territory of Constanţa County does not exceed the average figures recorded here and abroad, the global frequency within the studied time period is not satisfactory and imposes an assessing of the failure factors and measures of improvement.
这项工作旨在分析在康斯坦察县境内实际操作条件下进行的短期治疗中失败风险的质量，以此作为在计算机上应用数学分析方法以预测失败案例的前提。在290例病例中研究了262例符合条件的病例，这些病例代表了1982年在康斯坦察县新登记的肺结核患者总数，并且在治疗结束后对他们进行了3年的观察。结果出现了58例（22.1%）复发、治疗失败或治疗过程中纠正的治疗阳性反应，对这58例分析了25个可能的失败因素。最具代表性的被证明是组织因素，其中失败病例中治疗不规律（占67.2%）、动员治疗存在缺陷、技术因素：痰菌转阴延迟（治疗开始后超过4 - 5个月），以及在取决于患者的因素中——60.33%的失败病例出现了不合作情况。如果康斯坦察县境内失败的最终发生率未超过国内外在此记录的平均数字，那么在研究时间段内的总体发生率并不令人满意，这就需要对失败因素进行评估并采取改进措施。
