Iruzubieta Paula, Terán Álvaro, Crespo Javier, Fábrega Emilio
Paula Iruzubieta, Álvaro Terán, Javier Crespo, Emilio Fábrega, Gastroenterology and Hepatology Unit, Marqués de Valdecilla University Hospital, Instituto de Investigación Marqués de Valdecilla, 39008 Santander, Cantabria, Spain.
World J Hepatol. 2014 Dec 27;6(12):901-15. doi: 10.4254/wjh.v6.i12.901.
Vitamin D is an important secosteroid hormone with known effect on calcium homeostasis, but recently there is increasing recognition that vitamin D also is involved in cell proliferation and differentiation, has immunomodulatory and anti-inflammatory properties. Vitamin D deficiency has been frequently reported in many causes of chronic liver disease and has been associated with the development and evolution of non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC) virus infection. The role of vitamin D in the pathogenesis of NAFLD and CHC is not completely known, but it seems that the involvement of vitamin D in the activation and regulation of both innate and adaptive immune systems and its antiproliferative effect may explain its importance in these liver diseases. Published studies provide evidence for routine screening for hypovitaminosis D in patients with liver disease. Further prospectives studies demonstrating the impact of vitamin D replacement in NAFLD and CHC are required.
维生素D是一种重要的甾醇类激素，对钙稳态具有已知作用，但最近人们越来越认识到维生素D还参与细胞增殖和分化，具有免疫调节和抗炎特性。维生素D缺乏在许多慢性肝病病因中经常被报道，并与非酒精性脂肪性肝病（NAFLD）和慢性丙型肝炎（CHC）病毒感染的发生和发展有关。维生素D在NAFLD和CHC发病机制中的作用尚不完全清楚，但维生素D参与先天性和适应性免疫系统的激活和调节及其抗增殖作用似乎可以解释其在这些肝病中的重要性。已发表的研究为肝病患者常规筛查维生素D缺乏症提供了证据。需要进一步的前瞻性研究来证明维生素D替代疗法对NAFLD和CHC的影响。
