Zhao Da-Hang, Zhu Jiang, Wang Wen-Bo, Dong Feng, Zhang Qiao, Fan Hong-Wu, Zhang Jing-Zhe, Wang Yong-Ming
3rd Department of Orthopedics, The First Affiliated Hospital of Harbin Medical University, No. 23 Youzheng Street, Harbin 150001, China.
4th Department of Orthopedics, The Fourth Affiliated Hospital of Harbin Medical University, Harbin 150001, China.
ScientificWorldJournal. 2014;2014:837543. doi: 10.1155/2014/837543. Epub 2014 Nov 27.
We conducted a meta-analysis to comprehensively evaluate the correlations of ezrin expression with pathological characteristics and the prognosis of osteosarcoma. The MEDLINE (1966-2013), the Cochrane Library Database, EMBASE, CINAHL, Web of Science (1945-2013), and the Chinese Biomedical Database were searched without language restrictions. Meta-analyses conducted using STATA software were calculated. Ten studies met the inclusion criteria, including 459 patients with osteosarcoma. Meta-analysis results illustrated that ezrin expression may be closely associated with the recurrence of osteosarcoma or metastasis in osteosarcoma. Our findings also demonstrated that patients with grade III-IV osteosarcoma showed a higher frequency of ezrin expression than those with histological grade I-II osteosarcoma. Furthermore, we found that patients with positive expression of ezrin exhibited a shorter overall survival than those with negative ezrin expression. The results also indicated that positive ezrin expression was strongly correlated with poorer metastasis-free survival. Nevertheless, no significant relationships were observed between ezrin expression and clinical variables (age and gender). In the current meta-analysis, our results illustrated significant relationships of ezrin expression with pathological characteristics and prognosis of osteosarcoma. Thus, ezrin expression could be a promising marker in predicting the clinical outcome of patients with osteosarcoma.
我们进行了一项荟萃分析，以全面评估埃兹蛋白表达与骨肉瘤病理特征及预后的相关性。检索了MEDLINE（1966 - 2013年）、Cochrane图书馆数据库、EMBASE、CINAHL、Web of Science（1945 - 2013年）以及中国生物医学数据库，无语言限制。使用STATA软件进行荟萃分析计算。十项研究符合纳入标准，包括459例骨肉瘤患者。荟萃分析结果表明，埃兹蛋白表达可能与骨肉瘤的复发或转移密切相关。我们的研究结果还表明，III - IV级骨肉瘤患者埃兹蛋白表达频率高于组织学分级为I - II级的骨肉瘤患者。此外，我们发现埃兹蛋白表达阳性的患者总生存期短于埃兹蛋白表达阴性的患者。结果还表明，埃兹蛋白表达阳性与无转移生存期较差密切相关。然而，未观察到埃兹蛋白表达与临床变量（年龄和性别）之间存在显著关系。在当前的荟萃分析中，我们的结果表明埃兹蛋白表达与骨肉瘤的病理特征和预后存在显著关系。因此，埃兹蛋白表达可能是预测骨肉瘤患者临床结局的一个有前景的标志物。
