Department of Orthopedic Surgery, 1st Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Med Sci Monit. 2011 Aug;17(8):RA177-190. doi: 10.12659/msm.881893.
The most prevalent forms of bone cancer are osteosarcoma, chondrosarcoma, and Ewing's sarcoma. Although chemotherapy and radiotherapy have replaced traditional surgical treatments, survival rates have undergone only marginal improvements. Current knowledge of the molecular pathways involved in each type of cancer has led to better approaches in cancer treatment. A number of cell signaling molecules are involved in tumorigenesis, and specific targets have been identified based on these signal transducers. This review highlights some of the important cellular pathways and potential therapeutic targets, tumor site-specific irradiation techniques, and novel drug delivery systems used to administer these drugs.
最常见的骨癌类型包括骨肉瘤、软骨肉瘤和尤文肉瘤。尽管化疗和放疗已经取代了传统的手术治疗，但生存率仅略有提高。目前对每种癌症相关分子途径的认识已经导致了更好的癌症治疗方法。许多细胞信号分子参与肿瘤发生，并且已经基于这些信号转导物确定了特定的靶标。本综述强调了一些重要的细胞途径和潜在的治疗靶点、肿瘤部位特异性照射技术以及用于给予这些药物的新型药物输送系统。
