Bukhryakov Konstantin V, Desyatkin Victor G, O'Shea John-Paul, Almahdali Sarah R, Solovyeva Vera, Rodionov Valentin O
KAUST Catalysis Center and Division of Physical Sciences and Engineering, King Abdullah University of Science and Technology , Thuwal, 23955-6900, Kingdom of Saudi Arabia.
ACS Comb Sci. 2015 Feb 9;17(2):76-80. doi: 10.1021/co5001713. Epub 2015 Jan 13.
A rapid approach to identifying complementary catalytic groups using combinations of functional polymers is presented. Amphiphilic polymers with "clickable" hydrophobic blocks were used to create a library of functional polymers, each bearing a single functionality. The polymers were combined in water, yielding mixed micelles. As the functional groups were colocalized in the hydrophobic microphase, they could act cooperatively, giving rise to new modes of catalysis. The multipolymer "clumps" were screened for catalytic activity, both in the presence and absence of metal ions. A number of catalyst candidates were identified across a wide range of model reaction types. One of the catalytic systems discovered was used to perform a number of preparative-scale syntheses. Our approach provides easy access to a range of enzyme-inspired cooperative catalysts.
本文介绍了一种使用功能聚合物组合快速识别互补催化基团的方法。带有“可点击”疏水嵌段的两亲性聚合物被用于创建一个功能聚合物库，每个聚合物带有单一功能。这些聚合物在水中混合，形成混合胶束。由于功能基团在疏水微相中共定位，它们可以协同作用，产生新的催化模式。对多聚合物“团块”进行了有无金属离子存在下的催化活性筛选。在广泛的模型反应类型中鉴定出了许多催化剂候选物。所发现的一种催化体系被用于进行一些制备规模的合成。我们的方法为获得一系列受酶启发的协同催化剂提供了便捷途径。
