Zou X W, Huo J, Wang J M, Yuan J Y, Ma Y Y, Wang Q Y
Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Clin Exp Dermatol. 2015 Apr;40(3):309-12. doi: 10.1111/ced.12542. Epub 2014 Dec 26.
Fibroblastic rheumatism (FR) is a rare condition characterized by symmetrical polyarthritis and multiple cutaneous nodules. Approximately 30 cases have been reported worldwide to date. Laboratory tests are not particular useful to confirm the disease. Diagnosis is mainly dependent on the characteristic histopathological features: thickened collagen fibres with spindle-shaped cell proliferation in the skin lesion. We report a case of a 48-year-old Chinese man with typical clinical features of FR. In addition to the characteristic histopathological findings, multinuclear giant cell infiltration in skin lesions was detected, in this case. The evaluation of microelements revealed a raised blood lead level) of 129 μg/L (normal range 0-99 μg/L) These two features have never been described in the previous medical literature on FR. Thus, we propose that examining the infiltrated cells in detail in histopathological studies and inspecting the levels of lead and other microelements in the blood may increase our understanding of the pathogenesis of FR.
纤维母细胞性风湿病（FR）是一种罕见疾病，其特征为对称性多关节炎和多发性皮肤结节。迄今为止，全球报告的病例约有30例。实验室检查对确诊该病并无特别帮助。诊断主要依赖于特征性的组织病理学特征：皮肤病变处胶原纤维增厚并伴有梭形细胞增殖。我们报告一例48岁具有FR典型临床特征的中国男性病例。除了特征性的组织病理学表现外，该病例皮肤病变中还检测到多核巨细胞浸润。微量元素评估显示血铅水平升高至129μg/L（正常范围0 - 99μg/L）。这两个特征在以往关于FR的医学文献中从未有过描述。因此，我们建议在组织病理学研究中详细检查浸润细胞，并检测血液中铅及其他微量元素水平，这可能会增进我们对FR发病机制的理解。
