癌症治疗中的纳米医学：挑战、机遇与临床应用。

Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications.

机构信息

Division of Oncology, Department of Internal Medicine, University Hospital of Basel, Basel, Switzerland.

Division of Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.

出版信息

J Control Release. 2015 Feb 28;200:138-57. doi: 10.1016/j.jconrel.2014.12.030. Epub 2014 Dec 26.

DOI:10.1016/j.jconrel.2014.12.030

PMID:25545217

Abstract

Cancer is a leading cause of death worldwide. Currently available therapies are inadequate and spur demand for improved technologies. Rapid growth in nanotechnology towards the development of nanomedicine products holds great promise to improve therapeutic strategies against cancer. Nanomedicine products represent an opportunity to achieve sophisticated targeting strategies and multi-functionality. They can improve the pharmacokinetic and pharmacodynamic profiles of conventional therapeutics and may thus optimize the efficacy of existing anti-cancer compounds. In this review, we discuss state-of-the-art nanoparticles and targeted systems that have been investigated in clinical studies. We emphasize the challenges faced in using nanomedicine products and translating them from a preclinical level to the clinical setting. Additionally, we cover aspects of nanocarrier engineering that may open up new opportunities for nanomedicine products in the clinic.

摘要

癌症是全球主要的死亡原因。目前可用的治疗方法不足，因此需要改进技术。纳米技术的快速发展为开发纳米医学产品带来了很大的希望，这些产品有望改善癌症的治疗策略。纳米医学产品提供了实现复杂靶向策略和多功能性的机会。它们可以改善传统治疗药物的药代动力学和药效学特性，从而优化现有抗癌化合物的疗效。在这篇综述中，我们讨论了已经在临床研究中进行研究的最先进的纳米颗粒和靶向系统。我们强调了在使用纳米医学产品方面面临的挑战，以及将其从临床前水平转化为临床环境的挑战。此外，我们还涵盖了纳米载体工程的各个方面，这些方面可能为纳米医学产品在临床上开辟新的机会。