Division of Pediatric Hematology/Oncology, Gwynne Hazen Cherry Memorial Laboratories, Los Angeles, California 90095, USA.
Pediatr Res. 2010 May;67(5):514-9. doi: 10.1203/PDR.0b013e3181d601c5.
Although modern multimodal treatment of pediatric cancer has resulted in long-term cure of many patients, clinical success has come with significant acute and chronic morbidity. Targeted therapy using anticancer agents encapsulated in nanoparticles holds considerable promise in further improving efficacy and reducing toxic side effects. This review highlights the current strategies toward developing such therapeutic tools with an emphasis on using liposomes as flexible delivery vehicles. Potential strengths and technical difficulties encountered in advancing this platform are summarized. Critical functional determinants of nanoparticle delivery systems and future strategies to improve efficacy and specificity are described.
尽管现代多模式治疗儿科癌症已经使许多患者长期治愈，但临床成功带来了显著的急性和慢性发病率。使用纳米颗粒包裹的抗癌药物进行靶向治疗在进一步提高疗效和减少毒性副作用方面具有很大的潜力。本综述重点介绍了开发这种治疗工具的当前策略，强调使用脂质体作为灵活的递送载体。总结了推进这一平台所遇到的潜在优势和技术困难。描述了纳米颗粒递药系统的关键功能决定因素和提高疗效和特异性的未来策略。
