以色列人乳头瘤病毒相关口咽癌的趋势
Trends in human papillomavirus-related oropharyngeal cancer in Israel.
作者信息
Amit Moran, Ilana Kaplan, Avraham Sharon Pelles, Binenbaum Yoav, Bachar Gideon, Billan Salem, Zaarura Suliman, Czerninski Rakefet, Bar-Tov Matan, Maly Alexander, Akrish Sharon, Gil Ziv
机构信息
Department of Otolaryngology, Rambam Medical Center, The Technion, Israel Institute of Technology, Haifa, Israel.
Department of Pathology, Tel Aviv Medical Center, Tel Aviv, Israel.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E274-8. doi: 10.1002/hed.23985. Epub 2015 Jun 24.
BACKGROUND
The role of human papillomavirus (HPV) infection in oropharyngeal cancer (SCC) is well established. The annual incidence of oropharyngeal SCC in Israel is considerably lower than that in the United States. The purpose of this study was to assess the rate of HPV-related oropharyngeal SCC in Israel.
METHODS
The cohort included patients with oropharyngeal SCC who were treated during 1999 to 2011 in Israel. HPV typing was carried out using reverse hybridization and immunohistochemistry.
RESULTS
Of the 74 patients analyzed, 25 (33.7%) had detectable HPV DNA. Patients in the HPV-positive group tended to be younger, with a higher rate of nodal metastases, and no history of smoking (p < .02).
CONCLUSION
This study demonstrated a rate of HPV-related oropharyngeal SCC in Israel as approximately 3-fold lower than in Western countries. Low exposure to HPV-16, a lower rate of transformation, to cancer or protective genetic factors may contribute to the lower rate of oropharyngeal SCC in Israel. © 2015 Wiley Periodicals, Inc. Head Neck 38: E274-E278, 2016.
背景
人乳头瘤病毒（HPV）感染在口咽癌（鳞状细胞癌，SCC）中的作用已得到充分证实。以色列口咽鳞状细胞癌的年发病率显著低于美国。本研究的目的是评估以色列HPV相关口咽鳞状细胞癌的发生率。
方法
该队列包括1999年至2011年期间在以色列接受治疗的口咽鳞状细胞癌患者。采用反向杂交和免疫组织化学方法进行HPV分型。
结果
在分析的74例患者中，25例（33.7%）检测到HPV DNA。HPV阳性组患者往往更年轻，有更高的淋巴结转移率，且无吸烟史（p < 0.02）。
结论
本研究表明，以色列HPV相关口咽鳞状细胞癌的发生率约比西方国家低3倍。HPV-16暴露率低、癌症转化率低或存在保护性遗传因素可能导致以色列口咽鳞状细胞癌发生率较低。©2015威利期刊公司。头颈外科38: E274-E278，2016年。
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