Bahl Ankur, Kumar Pankaj, Dar Lalit, Mohanti Bidhu K, Sharma Atul, Thakar Alok, Karthikeyan Venkat, Sikka Kapil, Singh Chiromamit, Poo Kamala, Lodha Jaini
Department of Medical Oncology, Dr. B. R. A. Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, All India Institute of Medical Sciences, New Delhi, India.
Head Neck. 2014 Apr;36(4):505-10. doi: 10.1002/hed.23317. Epub 2013 Jun 1.
Human papillomavirus (HPV) prevalence in oropharyngeal squamous cell cancer (SCC) remains variable and studies have estimated that up to 60% may be positive.
One hundred five treatment-naïve oropharyngeal SCC patients were included. HPV genotyping was done by consensus polymerase chain reaction (PCR) and reverse line-blot hybridization assay. HPV prevalence was co-related with sex, age, tobacco consumption, alcohol use, and high-risk sexual behavior.
HPV prevalence was 22.8%. No significant associations were seen between tobacco or alcohol consumption with HPV status. The mean number of lifetime sexual partners and indulgence in high-risk sexual behavior was significantly more in patients who are HPV positive. There were no significant associations between the 2 groups with respect to the stage of the tumor.
Results of this study confirms that patients who are HPV positive are younger, and with high-risk sexual behavior. We did not find any impact of smoking and alcohol consumption on HPV status.
人乳头瘤病毒（HPV）在口咽鳞状细胞癌（SCC）中的流行率仍存在差异，研究估计高达60%可能呈阳性。
纳入105例未经治疗的口咽SCC患者。通过共识聚合酶链反应（PCR）和反向线印迹杂交分析进行HPV基因分型。HPV流行率与性别、年龄、烟草消费、饮酒及高危性行为相关。
HPV流行率为22.8%。未发现烟草或酒精消费与HPV状态之间存在显著关联。HPV阳性患者的终身性伴侣平均数量及高危性行为发生率显著更高。两组在肿瘤分期方面无显著关联。
本研究结果证实，HPV阳性患者更年轻，且有高危性行为。我们未发现吸烟和饮酒对HPV状态有任何影响。
