Hopper C D, Sparkes A H, Gruffydd-Jones T J, Crispin S M, Muir P, Harbour D A, Stokes C R
Department of Veterinary Medicine, University of Bristol, Langford.
Vet Rec. 1989 Sep 23;125(13):341-6. doi: 10.1136/vr.125.13.341.
Thirty-two cats referred to the Feline Studies Centre between June 1987 and October 1988, and 14 in-contact cats, were found to be infected with feline immunodeficiency virus. Most of the 46 cats were non-pedigree and free ranging; 27 were male (19 neutered) and 19 were female (18 neutered). Their ages ranged from one to 17 years and the average age was 5.8 years. The most common clinical signs were lethargy, inappetence, weight loss, pyrexia and lymphadenopathy; most cases had multiple abnormalities. Other common signs were gingivitis, diarrhoea, rhinitis and ocular discharge. Eight cats had neoplasia. The commonest haematological abnormalities were anaemia, neutropenia, lymphopenia and monocytosis. Eight cats had lymphocytosis; seven of these were in a single house-hold. Several cats had high serum globulin levels and half of those tested had high IgG levels. Seven cats had no detectable antibody to feline immunodeficiency virus even though the virus was cultured from the peripheral blood lymphocytes. During follow-up for up to 60 weeks one cat died and 23 were destroyed on humane grounds.
1987年6月至1988年10月间，有32只猫被送至猫科研究中心，另外还有14只接触过病猫的猫被发现感染了猫免疫缺陷病毒。这46只猫大多是非纯种的散养猫；其中27只是雄猫（19只已绝育），19只是雌猫（18只已绝育）。它们的年龄从1岁到17岁不等，平均年龄为5.8岁。最常见的临床症状是嗜睡、食欲不振、体重减轻、发热和淋巴结病；大多数病例有多种异常症状。其他常见症状有牙龈炎、腹泻、鼻炎和眼部分泌物增多。8只猫患有肿瘤。最常见的血液学异常是贫血、中性粒细胞减少、淋巴细胞减少和单核细胞增多。8只猫有淋巴细胞增多症；其中7只来自同一个家庭。几只猫的血清球蛋白水平较高，检测的猫中有一半IgG水平较高。7只猫即使在外周血淋巴细胞中培养出了病毒，也检测不到猫免疫缺陷病毒抗体。在长达60周的随访期间，有1只猫死亡，23只猫出于人道原因被安乐死。
