Veríssimo Luís M P, Cabral Ana M T D P V, Veiga Francisco J B, Almeida Sara F G, Ramos M Luisa, Burrows Hugh D, Esteso M A, Ribeiro Ana C F
Department of Chemistry, Coimbra Chemistry Centre, University of Coimbra, 3004-535 Coimbra, Portugal.
Faculty of Pharmacy, University of Coimbra, 3000-295 Coimbra, Portugal.
Int J Pharm. 2015 Feb 20;479(2):306-11. doi: 10.1016/j.ijpharm.2014.12.053. Epub 2014 Dec 26.
Mutual diffusion coefficients, densities and viscosities are reported for aqueous solutions of ethambutol as its dihydrochloride (EMBDHC) at finite concentrations and at 298.15K. From these experimental results and by using the appropriate models (Stokes-Einstein and Hartley), the hydrodynamic radii Rh, the diffusion coefficient at infinitesimal concentration D(0) and the thermodynamic factors, FT, have been estimated, permitting us to have a better understanding of the transport behavior of ethambutol dihydrochloride in solution. Elucidation of lack of any possible drug-drug interactions in these systems was obtained by complementary (1)H nuclear magnetic resonance (NMR) spectroscopy data.
报道了在298.15K下有限浓度的乙胺丁醇二盐酸盐（EMBDHC）水溶液的互扩散系数、密度和粘度。根据这些实验结果并使用适当的模型（斯托克斯-爱因斯坦模型和哈特利模型），估算了流体动力学半径Rh、无限稀释浓度下的扩散系数D(0)和热力学因子FT，这使我们能够更好地理解乙胺丁醇二盐酸盐在溶液中的传输行为。通过互补的氢核磁共振（NMR）光谱数据，阐明了这些体系中不存在任何可能的药物-药物相互作用。
