Chu Derek H, Goldbach Hayley, Wanat Karolyn A, Rubin Adam I, Yan Albert C, Treat James R
Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Pediatr Dermatol. 2015 Jul-Aug;32(4):518-21. doi: 10.1111/pde.12456. Epub 2014 Dec 28.
Localized changes in cutaneous elastic tissue often manifest with flesh-colored, hypopigmented, or yellow papules, plaques, and nodules. We present five children with clinically similar cobblestone plaques composed of multiple hypopigmented, nonfollicular, pinpoint papules located unilaterally over the upper chest. All lesions first appeared at birth or during early infancy. No associated extracutaneous abnormalities have been identified. Histopathology was remarkable for many, thick elastic fibers with elastorrhexis. We believe that these cases represent a distinct and unique variant of connective tissue nevi.
皮肤弹性组织的局部变化通常表现为肤色、色素减退或黄色丘疹、斑块和结节。我们报告了5例儿童患者，其临床表现为类似鹅卵石样的斑块，由多个色素减退、非毛囊性、针尖大小的丘疹单侧分布于上胸部。所有病变均在出生时或婴儿早期出现。未发现相关的皮肤外异常。组织病理学检查显示有许多粗大的弹性纤维并伴有弹性纤维断裂，非常显著。我们认为这些病例代表了结缔组织痣的一种独特变异型。
