Vannier P, Cariolet R
Zentralbl Veterinarmed B. 1989 Sep;36(7):515-26. doi: 10.1111/j.1439-0450.1989.tb00638.x.
A study was undertaken of the protection induced by inactivated and live Aujeszky's disease virus vaccines. The vaccines were administered using a special device which, without the use of a needle, delivered the preparation intradermally. The trials were performed on 88 pigs which were vaccinated at the beginning of the fattening period both in experimental conditions and in pig herds. All the pigs were challenged at the end of the fattening period in isolation units. The results obtained were compared with those obtained using the same vaccines injected intramuscularly. It was shown that vaccination via the intradermal route induced good protection in the vaccinated animals and was similar to that conferred by live virus vaccine injected intramuscularly. The results, with the inactivated virus vaccine, were not so good when it was injected via the intradermal route. Studies with intradermal vaccination showed no local lesion or very small nodules strictly localized to the dermis. The results also confirmed that the effects of challenge exposure depended on the health status of animals prior to infection and show the necessity to use a synthetic value (delta G) to interpret the data and mainly to compare the results objectively. In fattening pigs this vaccination procedure is attractive because (i) less animal constraint is needed than would be for intramuscular injections, (ii) injection can be checked by the presence of a visible papula at the site of inoculation and, (iii) pigs can be vaccinated in the ham while they are feeding. Injection without a needle also contributes to avoiding bacterial contamination under practical farm conditions of vaccination.
对灭活和活的奥耶斯基氏病病毒疫苗诱导的保护作用进行了一项研究。使用一种特殊装置接种疫苗，该装置无需使用针头即可进行皮内接种。试验在88头猪身上进行，这些猪在育肥期开始时在实验条件下和猪群中进行了接种。所有猪在育肥期结束时在隔离单元中接受攻毒。将获得的结果与肌肉注射相同疫苗所获得的结果进行比较。结果表明，皮内接种途径在接种动物中诱导了良好的保护作用，并且与肌肉注射活病毒疫苗所提供的保护作用相似。当通过皮内途径注射灭活病毒疫苗时，结果不太理想。皮内接种研究表明没有局部病变，或仅有严格局限于真皮的非常小的结节。结果还证实，攻毒暴露的影响取决于感染前动物的健康状况，并表明有必要使用一个综合值（δG）来解释数据，主要是为了客观地比较结果。在育肥猪中，这种接种程序具有吸引力，因为（i）与肌肉注射相比，所需的动物约束较少，（ii）可以通过接种部位出现可见丘疹来检查注射情况，并且（iii）猪在进食时可以在腿部进行接种。无针注射也有助于在实际农场接种条件下避免细菌污染。
