Teng Edmond, Chow Nicole, Hwang Kristy S, Thompson Paul M, Gylys Karen H, Cole Gregory M, Jack Clifford R, Shaw Leslie M, Trojanowski John Q, Soares Holly D, Weiner Michael W, Apostolova Liana G
Department of Neurology, University of California Los Angeles, Los Angeles, Calif., USA.
Dement Geriatr Cogn Disord. 2015;39(3-4):154-66. doi: 10.1159/000368982. Epub 2014 Dec 24.
Apolipoprotein E (APOE) genotype is the strongest known genetic risk factor for sporadic Alzheimer's disease (AD), but the utility of plasma ApoE levels for assessing the severity of underlying neurodegenerative changes remains uncertain. Here, we examined cross-sectional associations between plasma ApoE levels and volumetric magnetic resonance imaging indices of the hippocampus from 541 participants [57 with normal cognition (NC), 375 with mild cognitive impairment (MCI), and 109 with mild AD] who were enrolled in the Alzheimer's Disease Neuroimaging Initiative. Across the NC and MCI groups, lower plasma ApoE levels were significantly correlated with smaller hippocampal size, as measured by either hippocampal volume or hippocampal radial distance. These associations were driven primarily by findings from carriers of an APOE ε4 allele and are consistent with prior reports that lower plasma ApoE levels correlate with greater global cortical Pittsburgh Compound B retention. In this high-risk group, plasma ApoE levels may represent a peripheral marker of underlying AD neuropathology in nondemented elderly individuals.
载脂蛋白E（APOE）基因型是散发性阿尔茨海默病（AD）已知最强的遗传风险因素，但血浆载脂蛋白E水平用于评估潜在神经退行性变严重程度的效用仍不确定。在此，我们研究了来自阿尔茨海默病神经影像学计划的541名参与者[57名认知正常（NC）、375名轻度认知障碍（MCI）和109名轻度AD患者]血浆载脂蛋白E水平与海马体积磁共振成像指标之间的横断面关联。在NC组和MCI组中，血浆载脂蛋白E水平较低与海马体积较小显著相关，海马体积或海马径向距离均可衡量海马大小。这些关联主要由APOE ε4等位基因携带者的研究结果驱动，并且与先前报道一致，即较低的血浆载脂蛋白E水平与更高的全脑皮质匹兹堡复合物B保留率相关。在这个高危组中，血浆载脂蛋白E水平可能代表非痴呆老年人潜在AD神经病理学的外周标志物。
