Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
Department of Pathology, Hangzhou Normal University, Hangzhou, China.
Eur J Neurol. 2019 Nov;26(11):1362-1369. doi: 10.1111/ene.13987. Epub 2019 Jun 24.
The aim of this study was to determine the effects of apolipoprotein E ε4 (APOE ε4) genotype and sex together on longitudinal change in adjusted hippocampal volume [hippocampal volume:intracranial volume ratio (HpVR)] across the Alzheimer's disease (AD) continuum.
At baseline, we included 372 individuals with normal cognition (NC), 738 individuals with mild cognitive impairment (MCI) and 271 patients with mild AD from the Alzheimer's Disease Neuroimaging Initiative database. We examined the effects of the APOE ε4 by sex interaction on longitudinal change in HpVR within the overall sample and within each diagnostic group.
Female gender was found to be associated with longitudinal reduction of HpVR in the NC and MCI groups, but not in the AD group. Similarly, APOE ε4 was associated with longitudinal reduction of HpVR in the NC and MCI groups, but not in the AD group. Further, female APOE ε4 carriers showed a greater longitudinal reduction of HpVR than their male counterparts in the NC group, but not in the MCI or AD group. However, due to the relatively short duration of follow-up visits in patients with AD, further studies are needed to replicate these findings.
Female APOE ε4 carriers show a greater longitudinal reduction of HpVR than their male counterparts in cognitively normal older adults.
本研究旨在确定载脂蛋白 E ε4（APOE ε4）基因型和性别共同对阿尔茨海默病（AD）连续体中调整后的海马体积[海马体积：颅内体积比（HpVR）]的纵向变化的影响。
在基线时，我们纳入了来自阿尔茨海默病神经影像学倡议数据库的 372 名认知正常（NC）个体、738 名轻度认知障碍（MCI）个体和 271 名轻度 AD 患者。我们在整个样本和每个诊断组中检查了 APOE ε4 性别交互作用对 HpVR 纵向变化的影响。
发现女性性别与 NC 和 MCI 组的 HpVR 纵向减少相关，但与 AD 组无关。同样，APOE ε4 与 NC 和 MCI 组的 HpVR 纵向减少相关，但与 AD 组无关。此外，在 NC 组中，女性 APOE ε4 携带者的 HpVR 纵向减少幅度大于其男性携带者，但在 MCI 或 AD 组中则不然。然而，由于 AD 患者的随访时间相对较短，需要进一步的研究来复制这些发现。
在认知正常的老年人群中，女性 APOE ε4 携带者的 HpVR 纵向减少幅度大于其男性携带者。
