asperaculanes A 和 B，两种来自尖孢镰刀菌的倍半萜类化合物。
Asperaculanes A and B, two sesquiterpenoids from the fungus Aspergillus aculeatus.
机构信息
Shaanxi Key Laboratory of Natural Products Chemical Biology, College of Science, Northwest A&F University, Yangling 712100, Shaanxi, China.
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.
出版信息
Molecules. 2014 Dec 25;20(1):325-34. doi: 10.3390/molecules20010325.
Six sesquiterpenoids 1-6, including two new ones, an ent-daucane-type sesquiterpenoid, asperaculane A (1), and a nordaucane one, asperaculane B (2), and four known nordaucane derivatives, aculenes A-D 3-6, together with the known secalonic acid D (7), were isolated from a fermentation culture of the fungus Aspergillus aculeatus. Their structures and absolute configurations were established by analyses of their spectroscopic data, including 1D and 2D-NMR spectra, HR-ESIMS, electronic circular dichroism (ECD) data, and quantum chemical calculations. These metabolites were evaluated for in vitro cytotoxic activity against two cell lines, human cancer cell lines (HeLa) and one normal hamster cell line (CHO).
从真菌 Aspergillus aculeatus 的发酵培养物中分离得到了 6 种倍半萜类化合物 1-6，包括 2 种新化合物，一种 ent-daucane 型倍半萜，asperaculane A（1）和一种 nordaucane 型倍半萜，asperaculane B（2），以及 4 种已知的 nordaucane 衍生物 aculenes A-D（3-6），以及已知的 secalonic acid D（7）。通过分析其光谱数据，包括 1D 和 2D-NMR 光谱、高分辨率电喷雾电离质谱（HR-ESIMS）、电子圆二色性（ECD）数据和量子化学计算，确定了它们的结构和绝对构型。这些代谢产物对两种细胞系（人癌细胞系 HeLa 和一种正常仓鼠细胞系 CHO）的体外细胞毒性活性进行了评估。
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