从益智果实中分离得到的四种新倍半萜类化合物。

Four new sesquiterpenoids from the fruits of Alpinia oxyphylla.

作者信息

Lv Xiao-Qing, Luo Jian-Guang, Wang Xiao-Bing, Wang Jun-Song, Luo Jun, Kong Ling-Yi

机构信息

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, People's Republic of China.

出版信息

Chem Pharm Bull (Tokyo). 2011;59(3):402-6. doi: 10.1248/cpb.59.402.

DOI:10.1248/cpb.59.402

PMID:21372427

Abstract

Two new norsesquiterpenoids, oxyphyllenotriol A (1) and oxyphyllone G (2), and two new sesquiterpenoids, oxyphyllol D (3) and oxyphyllol E (4), together with two known compounds (5, 6) were isolated from the fruits of Alpinia oxyphylla. Their structures were determined on the basis of spectroscopic analysis, including high resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1D- and 2D-NMR, and the absolute configurations of 2 and 4 were determined by theoretical calculation of electronic circular dichroism (ECD) and comparison with the experimental ECD spectra.

摘要

从益智果实中分离得到两个新的降倍半萜类化合物，氧化叶益智三醇A（1）和氧化叶益智酮G（2），以及两个新的倍半萜类化合物，氧化叶益智醇D（3）和氧化叶益智醇E（4），同时还得到两个已知化合物（5, 6）。通过高分辨电喷雾电离质谱（HR-ESI-MS）、一维和二维核磁共振等光谱分析确定了它们的结构，2和4的绝对构型通过电子圆二色光谱（ECD）的理论计算并与实验ECD光谱进行比较来确定。