海绵附生真菌 Aspergillus sydowii SCSIO41301 中结构多样的倍半萜和聚酮化合物。
Structurally diverse sesquiterpenoids and polyketides from a sponge-associated fungus Aspergillus sydowii SCSIO41301.
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine MateriaMedica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China; College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China.
Guangdong Provincial Key Laboratory of New Drug Screening, Guangzhou Key Laboratory of Drug Research for EmergingVirusPrevention and Treatment, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China.
出版信息
Fitoterapia. 2019 Jun;135:27-32. doi: 10.1016/j.fitote.2019.03.031. Epub 2019 Apr 1.
Five new compounds, including one bisabolane-type sesquiterpenoids, namely aspergillusene D (1), two new xanthones (2 and 3), and two new catecholderivatives (4 and 5), together with fourteen known compounds (6-19), were isolated and identified from the fungus Aspergillus sydowiiSCSIO 41,301 from the sponge Phakellia fusca. Their structures and absolute configurations were determined by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. Most of the isolated compounds (1-3, and 6-19) were evaluated for their antiviral, cytotoxic, and antibacterial activities. Among them, new compounds 2 and 3 displayed obvious selective inhibitory activities against two influenza A virus subtypes, including A/Puerto Rico/8/34 (H1N1) and A/FM-1/1/47 (H1N1), with IC values ranging from 2.17 ± 1.39 to 4.70 ± 1.11 μM.
从海绵 Phakellia fusca 中分离到的真菌 Aspergillus sydowii SCSIO 41,301 中，分离并鉴定出了五个新化合物，包括一个双倍半萜类化合物aspergillusene D（1），两个新的酮（2 和 3）和两个新的儿茶酚衍生物（4 和 5），以及 14 个已知化合物（6-19）。通过广泛的光谱分析和电子圆二色性（ECD）计算确定了它们的结构和绝对构型。对分离得到的大多数化合物（1-3 和 6-19）进行了抗病毒、细胞毒性和抗菌活性评价。其中，新化合物 2 和 3 对两种甲型流感病毒亚型（包括 A/Puerto Rico/8/34（H1N1）和 A/FM-1/1/47（H1N1））表现出明显的选择性抑制活性，IC 值范围为 2.17±1.39 至 4.70±1.11μM。
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