Li Hong, Yuan Xiaolan, Liu Lu, Zhou Jiaojiao, Li Chunyan, Yang Peng, Bu Le, Zhang Manna, Qu Shen
Department of Endocrinology, Shanghai Tenth People's Hospital, . Tongji University School of Medicine, 301 Yanchang Middle Road, Shanghai 200072, China.
Int J Endocrinol. 2014;2014:618572. doi: 10.1155/2014/618572. Epub 2014 Dec 8.
To clarify the clinical value of serums total triiodothyronine (TT3), total thyroxine (TT4), free triiodothyronine (FT3), and free thyroxine (FT4) and provide a more eligible and economic strategy to assess thyroid function. A total of 2,673 participants (500 patients with hyperthyroidism, 500 patients with hypothyroidism, and 1,673 healthy people) were involved in our study. Serums TT3, TT4, FT3, and FT4 and thyrotropin (TSH) were measured with VIDAS fluorescent enzyme immunoassay. The Pearson correlation between TT3, TT4, FT3, and FT4 and TSH was determined to identify the most important indicator for thyroid function besides TSH. The correlation of TT4, and FT4 with TSH was statistically significant in healthy individuals (P < 0.01), and the R-values were -0.065 and -0.152, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hyperthyroidism, and the R-values were -0.241, -0.225, -0.195, and -0.176, respectively. The correlation of TT4, FT4, TT3, and FT3 with TSH was statistically significant in patients with hypothyroidism, and the R-values were -0.322, -0.262, -0.179, and -0.136, respectively. In our opinion, TSH and FT4 are the most valuable indicators in assessing thyroid function in a healthy population, and TSH and TT4 are the most meaningful in hyperthyroidism and hypothyroidism.
为阐明血清总三碘甲状腺原氨酸（TT3）、总甲状腺素（TT4）、游离三碘甲状腺原氨酸（FT3）和游离甲状腺素（FT4）的临床价值，并提供一种更合适且经济的甲状腺功能评估策略。我们的研究共纳入了2673名参与者（500例甲状腺功能亢进患者、500例甲状腺功能减退患者和1673名健康人）。采用VIDAS荧光酶免疫分析法检测血清TT3、TT4、FT3、FT4和促甲状腺激素（TSH）。确定TT3、TT4、FT3、FT4与TSH之间的Pearson相关性，以确定除TSH外甲状腺功能最重要的指标。在健康个体中，TT4和FT4与TSH的相关性具有统计学意义（P < 0.01），R值分别为-0.065和-0.152。在甲状腺功能亢进患者中，TT4、FT4、TT3和FT3与TSH的相关性具有统计学意义，R值分别为-0.241、-0.225、-0.195和-0.176。在甲状腺功能减退患者中，TT4、FT4、TT3和FT3与TSH的相关性具有统计学意义，R值分别为-0.322、-0.262、-0.179和-0.136。我们认为，TSH和FT4是评估健康人群甲状腺功能最有价值的指标，而TSH和TT4在甲状腺功能亢进和减退中最具意义。
