Mullins Brandon T, Hackman Trevor
University of North Carolina School of Medicine, 1033 Bondurant Hall, Chapel Hill, NC 27514, USA.
Division of Otolaryngology, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27514, USA.
Case Rep Otolaryngol. 2014;2014:368920. doi: 10.1155/2014/368920. Epub 2014 Dec 4.
Background. Malignant peripheral nerve sheath tumors (MPNSTs) of the head and neck are rare aggressive neoplasms with a poor prognosis. This study describes the management and outcomes of 3 of our patients with MPNSTs of the head and neck. Methods. We identified 3 patients presenting with MPNST of the head and neck and treated at the University of North Carolina. We compared our results to the literature from 1963 to 2014. Results. Mean follow-up was 31 months. Average age at diagnosis was 44.7 years of age. All patients received wide-local excision and adjuvant radiotherapy. No patients recurred during the series. Recurrence-free survival time for the patients was 45, 37, and 3 months, respectively. Conclusions. Our data series confirms that a combined-modality approach with complete surgical resection and adjuvant radiotherapy leads to improved outcomes in MPNSTs of the head and neck. Nonetheless, due to historically poor outcomes, continued research into newer therapies needs to be explored.
背景。头颈部恶性外周神经鞘瘤（MPNSTs）是罕见的侵袭性肿瘤，预后较差。本研究描述了我们治疗的3例头颈部MPNSTs患者的治疗情况及结果。方法。我们确定了3例头颈部MPNSTs患者，他们在北卡罗来纳大学接受治疗。我们将我们的结果与1963年至2014年的文献进行了比较。结果。平均随访时间为31个月。诊断时的平均年龄为44.7岁。所有患者均接受了广泛局部切除和辅助放疗。该系列中无患者复发。患者的无复发生存时间分别为45个月、37个月和3个月。结论。我们的数据系列证实，采用完全手术切除和辅助放疗的综合治疗方法可改善头颈部MPNSTs的治疗效果。尽管如此，由于历史上治疗效果较差，仍需探索对更新疗法的持续研究。
