Kim Min Ji, Han Sang Young, Baek Yang Hyun, Lee Sung Wook, Kwon Hee Jin
Department of Gastroenterology, Dong-A University College of Medicine, Busan, Korea.
Department of Radiology, Dong-A University College of Medicine, Busan, Korea.
Clin Mol Hepatol. 2014 Dec;20(4):392-7. doi: 10.3350/cmh.2014.20.4.392. Epub 2014 Dec 24.
Focal nodular hyperplasia (FNH) is the second most common benign solid tumor of the liver and is usually found in young females. In FNH, spontaneous bleeding or rupture rarely occurs and malignant transformation is unlikely. The etiology of FNH is unclear, but because of female predominance and young age at onset, it seems that female hormone has an important role for the development of FNH. Although the development and the complications of hepatocellular adenomas have been related to the use of oral contraceptives and pregnancy, the influence of oral contraceptives and pregnancy on the growth and complications of FNH is controversial. Most FNH are stable in size and rarely complicated during pregnancy. We describe here a case of FNH with growth progression during pregnancy in a 27-year-old female. Her course of pregnancy and delivery was uneventful. Two months after delivery, the size of FNH was decreased.
局灶性结节性增生(FNH)是肝脏第二常见的良性实性肿瘤,多见于年轻女性。FNH很少发生自发性出血或破裂,也不太可能发生恶变。FNH的病因尚不清楚,但由于女性占主导且发病年龄较轻,雌激素似乎在FNH的发生发展中起重要作用。虽然肝细胞腺瘤的发生及并发症与口服避孕药和妊娠有关,但口服避孕药和妊娠对FNH生长及并发症的影响仍存在争议。大多数FNH大小稳定,孕期很少出现并发症。我们在此描述一例27岁女性在孕期FNH生长进展的病例。她的妊娠和分娩过程顺利。产后两个月,FNH体积缩小。