Ashhab Ashraf A, Abu-Sulb Ahmad, Yang Ju Dong, Noureddin Mazen, Sundaram Vinay, Kuo Alexander, Ayoub Walid S
Division of Digestive and Liver Diseases, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Division of Pediatrics, Legacy Community Health, Houston, TX.
ACG Case Rep J. 2021 Jan 13;8(1):e00531. doi: 10.14309/crj.0000000000000531. eCollection 2021 Jan.
The etiologic association between focal nodular hyperplasia (FNH) and estrogen has been a subject of doubt and controversy. We present a case of a female patient with FNH that had been monitored for several years with noted size stability and later regression, who developed tumor growth during pregnancy. This case suggests that a subset of FNH is indeed hormone sensitive, as opposed to what has been frequently suggested by many other reports that question the association, a finding that may have clinical implications, in terms of monitoring of patients with high estrogen statuses.
局灶性结节性增生（FNH）与雌激素之间的病因学关联一直存在疑问和争议。我们报告一例患有FNH的女性患者，该患者多年来接受监测，结节大小稳定，随后缩小，但在孕期肿瘤却出现生长。该病例表明，与许多其他质疑这种关联的报告所经常暗示的情况相反，一部分FNH确实对激素敏感，这一发现可能对处于高雌激素状态患者的监测具有临床意义。
