Wu Meng-Chieh, Huang Chun-Yi, Kuo Fu-Chen, Hsu Wen-Hung, Wang Sophie S W, Shih Hsiang-Yao, Liu Chung-Jung, Chen Yen-Hsu, Wu Deng-Chyang, Huang Yeou-Lih, Lu Chien-Yu
Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung 812, Taiwan ; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan.
Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan ; Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Biomed Res Int. 2014;2014:513725. doi: 10.1155/2014/513725. Epub 2014 Jun 26.
This study was designed to compare the effect of Helicobacter pylori (H. pylori) infection treatment on serum zinc, copper, and selenium levels.
We measured the serum zinc, copper, and selenium levels in H. pylori-positive and H. pylori-negative patients. We also evaluated the serum levels of these trace elements after H. pylori eradication. These serum copper, zinc, and selenium levels were determined by inductively coupled plasma mass spectrometry.
Sixty-three H. pylori-positive patients and thirty H. pylori-negative patients were studied. Serum copper, zinc, and selenium levels had no significant difference between H. pylori-positive and H. pylori-negative groups. There were 49 patients with successful H. pylori eradication. The serum selenium levels were lower after successful H. pylori eradication, but not significantly (P = 0.06). There were 14 patients with failed H. pylori eradication. In this failed group, the serum selenium level after H. pylori eradication therapy was significantly lower than that before H. pylori eradication therapy (P < 0.05). The serum zinc and copper levels had no significant difference between before and after H. pylori eradication therapies.
H pylori eradication regimen appears to influence the serum selenium concentration (IRB number: KMUH-IRB-20120327).
本研究旨在比较幽门螺杆菌（H. pylori）感染治疗对血清锌、铜和硒水平的影响。
我们测量了幽门螺杆菌阳性和阴性患者的血清锌、铜和硒水平。我们还评估了幽门螺杆菌根除后这些微量元素的血清水平。这些血清铜、锌和硒水平通过电感耦合等离子体质谱法测定。
研究了63例幽门螺杆菌阳性患者和30例幽门螺杆菌阴性患者。幽门螺杆菌阳性组和阴性组之间的血清铜、锌和硒水平无显著差异。49例患者幽门螺杆菌根除成功。幽门螺杆菌成功根除后血清硒水平降低，但差异不显著（P = 0.06）。14例患者幽门螺杆菌根除失败。在这个失败组中，幽门螺杆菌根除治疗后的血清硒水平显著低于幽门螺杆菌根除治疗前（P < 0.05）。幽门螺杆菌根除治疗前后血清锌和铜水平无显著差异。
幽门螺杆菌根除方案似乎会影响血清硒浓度（伦理审查委员会编号：KMUH-IRB-20120327）。
