*Division of Cosmetic Science, University of Hamburg, Hamburg, Germany; †Rosenpark Research, Darmstadt, Germany; ‡Scientific Communication and Information, Oxford, United Kingdom.
Dermatol Surg. 2015 Jan;41 Suppl 1:S29-38. doi: 10.1097/DSS.0000000000000274.
Botulinum toxins are used for facial rejuvenation.
To investigate the efficacy, patient satisfaction, and skin physiology after incobotulinumtoxinA treatment of the upper face.
Thirty women aged 35 to 55 were enrolled in this single-center prospective 16-week study. Patients and an investigator blinded to visit number assessed wrinkle severity after incobotulinumtoxinA treatment of glabellar, periorbital, and forehead lines using Validated Assessment Scales at Days 0 (baseline), 2, 7, 14, 28, and 112. Responder rates (for each region) and mean wrinkle scores (whole upper face) were calculated. Treatment satisfaction was self-assessed by questionnaire. Transepidermal water loss (TEWL), stratum corneum hydration, and skin pH were measured to assess skin barrier function.
Wrinkle severity decreased rapidly after treatment. Responder rates generally peaked at Days 7 to 14. At 112 days, mean scores remained significantly lower than baseline (p < .05). Patients were significantly more satisfied with their appearance after treatment; most felt "younger" and "more attractive" (p < .05). Transepidermal water loss decreased significantly throughout (p < .05), and stratum corneum hydration increased. No treatment-related adverse events occurred.
IncobotulinumtoxinA rapidly improved wrinkle severity, and improvements were maintained for up to 112 days. Increased stratum corneum hydration and reduced TEWL may improve skin quality. IncobotulinumtoxinA was well tolerated and improved patients' self-perception.
肉毒毒素用于面部年轻化。
研究上脸应用 incobotulinumtoxinA 治疗的疗效、患者满意度和皮肤生理学变化。
本单中心前瞻性 16 周研究纳入 35 至 55 岁的 30 名女性。患者和一位对访视次数不知情的研究者在第 0 天（基线）、第 2 天、第 7 天、第 14 天、第 28 天和第 112 天，使用经过验证的评估量表评估 incobotulinumtoxinA 治疗眉间纹、眶周纹和额纹后皱纹严重程度。计算各区域（和整个上脸）的应答率（应答者比例）和平均皱纹评分。通过问卷评估治疗满意度。测量经皮水分丢失（TEWL）、角质层含水量和皮肤 pH 值以评估皮肤屏障功能。
治疗后皱纹严重程度迅速下降。应答率通常在第 7 天至 14 天达到峰值。在第 112 天，平均评分仍显著低于基线（p <.05）。治疗后患者对自己的外观明显更满意；大多数人感觉“更年轻”和“更有吸引力”（p <.05）。TEWL 一直显著下降（p <.05），角质层含水量增加。未发生与治疗相关的不良事件。
incobotulinumtoxinA 可迅速改善皱纹严重程度，疗效可持续长达 112 天。角质层含水量增加和 TEWL 减少可能改善皮肤质量。incobotulinumtoxinA 耐受性良好，可改善患者的自我认知。
