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重复使用阿 Botox（保妥适）、透明质酸填充剂和皮肤增强型透明质酸进行全脸美学联合治疗，在单独使用阿 Botox（保妥适）或透明质酸填充剂治疗后。

Repeated Full-Face Aesthetic Combination Treatment With AbobotulinumtoxinA, Hyaluronic Acid Filler, and Skin-Boosting Hyaluronic Acid After Monotherapy With AbobotulinumtoxinA or Hyaluronic Acid Filler.

机构信息

Centre Medical Saint-Jean, Arras, France.

Akademikliniken, Stockholm, Sweden.

出版信息

Dermatol Surg. 2020 Apr;46(4):475-482. doi: 10.1097/DSS.0000000000002165.

DOI:10.1097/DSS.0000000000002165
PMID:31592825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7147415/
Abstract

BACKGROUND

Full-face aesthetic treatment involving several treatment modalities may improve facial aesthetic outcome.

OBJECTIVE

To evaluate clinical outcomes and patient perceptions of monotherapy with either abobotulinumtoxinA (ABO) or hyaluronic acid (HA) filler followed by full-face combination treatments of ABO, HA filler, and skin-boosting HA (RSB).

MATERIALS AND METHODS

Subjects aged 35 to 50 years were randomized to monotherapy with 50 s.U ABO in the glabella or ≤1 mL HA filler in the nasolabial folds (NLFs)/cheeks. At Month 6 and Month 12, all subjects received combination treatment with ≤50 s.U ABO in the glabella, ≤2 mL HA filler in the NLFs/cheeks (and other facial areas as applicable), and ≤1 mL RSB (additional RSB treatment at Month 7). Assessments included global facial aesthetic appearance and improvement, first impression, perceived age, wrinkle severity, satisfaction questionnaires, and adverse events.

RESULTS

Repeated full-face combination treatment with ABO, HA filler, and RSB was associated with considerably higher levels of aesthetic improvement and subject satisfaction than monotherapy with ABO or HA filler. Improvement rate of glabellar lines was increasing with each treatment.

CONCLUSION

Repeated combination treatment achieved greater change in global facial aesthetic appearance than monotherapy. Aesthetic improvement and subject satisfaction was high and increased with each treatment. All treatments were well tolerated.

摘要

背景

涉及多种治疗方式的全面部美学治疗可能会改善面部美学效果。

目的

评估肉毒毒素 A（ABO）或透明质酸（HA）填充剂单药治疗后再进行 ABO、HA 填充剂和皮肤增强型 HA（RSB）全面部联合治疗的临床效果和患者认知。

材料和方法

年龄在 35 至 50 岁之间的受试者被随机分配接受 50 个单位 ABO 治疗眉间或 ≤1 毫升 HA 填充剂治疗鼻唇沟/脸颊。在第 6 个月和第 12 个月，所有受试者均接受联合治疗，即 ≤50 个单位 ABO 治疗眉间，≤2 毫升 HA 填充剂治疗鼻唇沟/脸颊（和其他适用的面部区域），≤1 毫升 RSB（第 7 个月追加 RSB 治疗）。评估包括整体面部美学外观和改善、第一印象、感知年龄、皱纹严重程度、满意度问卷和不良事件。

结果

与 ABO 或 HA 填充剂单药治疗相比，ABO、HA 填充剂和 RSB 的重复全面部联合治疗与更高水平的美学改善和患者满意度相关。眉间线的改善率随着每次治疗而增加。

结论

重复联合治疗在整体面部美学外观上的改善程度大于单药治疗。美学改善和患者满意度高，且随着每次治疗而增加。所有治疗均耐受良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/dbcf76c76efa/ds-46-475-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/abbb4cb309c9/ds-46-475-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/2ad10bff3a41/ds-46-475-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/b63676eca7ef/ds-46-475-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/6770804bfd39/ds-46-475-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/31a652de3b1c/ds-46-475-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/dbcf76c76efa/ds-46-475-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/abbb4cb309c9/ds-46-475-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/2ad10bff3a41/ds-46-475-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/b63676eca7ef/ds-46-475-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/6770804bfd39/ds-46-475-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/31a652de3b1c/ds-46-475-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b81/7147415/dbcf76c76efa/ds-46-475-g006.jpg

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