*Prager and Partner, Derma-Hamburg, Hamburg, Germany; †Praxis für Dermatologie, Hautarztpraxis Stengel and Bee, Munster, Germany; ‡SCIderm GmbH, Hamburg, Germany.
Dermatol Surg. 2015 Jan;41 Suppl 1:S88-92. doi: 10.1097/DSS.0000000000000177.
IncobotulinumtoxinA improves the appearance of facial rhytides and the aging neck.
To investigate the efficacy, safety, and subject satisfaction of incobotulinumtoxinA for platysmal band treatment.
Subjects (n = 23) with 2 to 4 platysmal bands (scoring ≥1 on a newly validated 5-point assessment scale) were enrolled. IncobotulinumtoxinA (15 U) was administered to each band. Assessments, using the 5-point scale, occurred at 6 posttreatment visits over 5 months. Adverse events were recorded and subjects self-assessed the appearance of their platysmal bands versus baseline.
At maximum tension, a response (≥1-point improvement from baseline score) was observed in 65.2% of subjects 3 (±1) days posttreatment, rising to 100% on Day 8 (±1). The change from baseline in the mean score was significant at each time point, including the final visit (Weeks 20-21). Response rates were higher at maximum tension than at rest. The peak effect occurred later at rest than at maximum tension. No serious adverse event occurred. At maximum tension, 69.6%, 73.9%, and 68.2% of subjects rated their platysmal bands as "improved" or "markedly improved" at Visits 2, 3, and 4, respectively.
IncobotulinumtoxinA is an effective and well-tolerated treatment for platysmal bands, with a rapid onset and long duration of effect.
IncobotulinumtoxinA 可改善面部皱纹和衰老颈部的外观。
研究 IncobotulinumtoxinA 治疗颈阔肌带的疗效、安全性和患者满意度。
纳入 23 例颈阔肌带 2-4 条（新验证的 5 分评估量表评分≥1）的受试者。每条带给予 IncobotulinumtoxinA（15U）。在 5 个月的 6 次治疗后访视中，使用 5 分制进行评估。记录不良事件，并由受试者自我评估颈阔肌带相对于基线的外观。
在最大张力时，65.2%的受试者在治疗后 3（±1）天出现反应（与基线评分相比≥1 分改善），在第 8 天（±1）时上升至 100%。在每个时间点，包括最后一次访视（第 20-21 周），从基线的平均评分变化均具有统计学意义。在最大张力时的反应率高于在休息时。在休息时的峰值效果晚于在最大张力时。未发生严重不良事件。在最大张力时，分别有 69.6%、73.9%和 68.2%的受试者在第 2、3 和 4 次访视时将其颈阔肌带评为“改善”或“显著改善”。
IncobotulinumtoxinA 是一种有效且耐受性良好的颈阔肌带治疗方法，起效迅速，作用持续时间长。
