Barbosa Teresa M, Phelan Robert W, Leong Dara, Morrissey John P, Adams Claire, Dobson Alan D W, O'Gara Fergal
School of Pharmacy, University College Cork, Cork, Ireland.
Department of Microbiology, University College Cork, Cork, Ireland; Biomerit Research Centre, University College Cork, Cork, Ireland.
PLoS One. 2014 Dec 30;9(12):e115583. doi: 10.1371/journal.pone.0115583. eCollection 2014.
A better understanding of the origin and natural reservoirs of resistance determinants is fundamental to efficiently tackle antibiotic resistance. This paper reports the identification of a novel 5.8 kb erythromycin resistance plasmid, from Bacillus sp. HS24 isolated from the marine sponge Haliclona simulans. pBHS24B has a mosaic structure and carries the erythromycin resistance gene erm(T). This is the first report of an erythromycin resistance plasmid from a sponge associated bacteria and of the Erm(T) determinant in the genus Bacillus.
更好地了解耐药决定因素的起源和天然储存库是有效应对抗生素耐药性的基础。本文报道了从海洋海绵拟半枝花Haliclona simulans中分离出的芽孢杆菌属HS24菌株中鉴定出一种新型的5.8 kb红霉素耐药质粒。pBHS24B具有嵌合结构，并携带红霉素耐药基因erm(T)。这是首次报道来自海绵相关细菌的红霉素耐药质粒以及芽孢杆菌属中的Erm(T)决定因素。
