从与海洋海绵相关的 中分离得到的二酮哌嗪的结构阐明和抗菌活性。
Structural elucidation and antimicrobial activity of a diketopiperazine isolated from a sp. associated with the marine sponge .
机构信息
School of Environmental Studies, Jadavpur University , Kolkata , India.
Department of Chemistry, Vidyasagar Evening College , Kolkata , India.
出版信息
Nat Prod Res. 2021 Jul;35(14):2315-2323. doi: 10.1080/14786419.2019.1672684. Epub 2019 Oct 4.
A diketopiperazine (3, 6)-3,6-diisobutylpiperazine-2,5-dione was isolated from a sponge-associated microbe for the first time and characterized by FTIR, HRESI-MS, H, C NMR and 2D NMR. The source is novel for this compound. Single crystal XRD of this diketopiperazine obtained as a natural product was analysed for the first time and its melting point was determined to be 262 °C. MICs of this cyclic dipeptide against and were 16 µg mL and 22 µg mL respectively, the first report of antibacterial activity of this diketopiperazine.Supplemental data for this article can be accessed at https://doi.org/10.1080/14786419.2019.1672684.
一种二酮哌嗪（3,6）-3,6-二异丁基哌嗪-2,5-二酮首次从一种与海绵相关的微生物中分离出来，并通过傅里叶变换红外光谱（FTIR）、高分辨率电喷雾电离质谱（HRESI-MS）、氢（H）、碳（C）核磁共振（NMR）和二维 NMR 进行了表征。该化合物的来源是新颖的。首次对作为天然产物获得的这种二酮哌嗪的单晶 XRD 进行了分析，并确定其熔点为 262°C。该环状二肽对 和 的最小抑菌浓度（MIC）分别为 16µg mL 和 22µg mL，这是该二酮哌嗪具有抗菌活性的首次报道。本文的补充数据可在 https://doi.org/10.1080/14786419.2019.1672684 上获取。
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