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挽救不可挽救的骨巨细胞瘤:“纵向三明治技术”

Salvaging the Unsalvageable Giant Cell Tumors of Bone: The 'Longitudinal Sandwich Technique'.

作者信息

Poudel Rishi Ram, Tiwari Akshay, Jain Aakriti, Verma Vivek

机构信息

Division of Musculoskeletal Oncology, Department of Surgical Oncology, Nepal Cancer Hospital & Research Center, Lalitpur, Nepal.

Division of Musculoskeletal Oncology, Department of Surgical Oncology, Max Institute of Cancer Care, New Delhi, India.

出版信息

Indian J Surg Oncol. 2022 Jun;13(2):316-321. doi: 10.1007/s13193-022-01545-3. Epub 2022 May 6.

Abstract

Management of Campanacci Grade III Giant Cell Tumors of bone (GCT) is challenging. Although selected cases of Grade III GCTs can still be managed with intralesional extended curettage, wide excision of the lesion is usually recommended when there is extensive cortical destruction. This study describes the outcome of 'longitudinal sandwich technique' for extended curettage of Grade III GCTs with more than 50% cortical destruction. Here, the deficiency of cortex was made up for by using bone graft/graft substitute, used alongside cement placed in a longitudinal fashion. Twelve patients operated with this technique between Jan 2012 and Jan 2018 were reviewed. Majority of the lesions involved the lower limbs. Bone graft was used in eight whereas commercial bone graft substitute was used in the remaining four, along with bone cement in all. On follow-up ranging from 38 to 84 months (median follow-up 59 months), there were 4 local recurrences (33.33%). All recurrences were managed successfully with repeat surgery without the need for bony resection. Mean MSTS score during the last follow-up was 25.08 ± 2.31 and all patients were disease-free during the last follow-up. 'Longitudinal sandwich technique' helps to expand the indications of extended curettage even for aggressive Grade III GCTs, with satisfactory outcomes.

摘要

骨巨细胞瘤(GCT)Campanacci III级的治疗具有挑战性。尽管部分III级GCT病例仍可通过病灶内扩大刮除术进行治疗,但当出现广泛的皮质破坏时,通常建议对病变进行广泛切除。本研究描述了“纵向三明治技术”用于皮质破坏超过50%的III级GCT扩大刮除术的结果。在此,皮质缺损通过使用骨移植/移植替代物来弥补,同时纵向放置骨水泥。回顾了2012年1月至2018年1月间采用该技术手术的12例患者。大多数病变累及下肢。8例使用了骨移植,其余4例使用了商用骨移植替代物,均同时使用了骨水泥。随访时间为38至84个月(中位随访时间59个月),有4例局部复发(33.33%)。所有复发均通过再次手术成功处理,无需进行骨切除。最后一次随访时的平均MSTS评分为25.08±2.31,所有患者在最后一次随访时均无疾病。“纵向三明治技术”有助于扩大扩大刮除术的适应证,即使对于侵袭性III级GCT,也能取得满意的结果。

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本文引用的文献

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Giant cell tumors of the sacrum: is non-operative treatment effective?骶骨巨细胞瘤:非手术治疗有效吗?
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Excisional Curettage of Benign Cystic Lesions.良性囊性病变的切除刮除术
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