Meng Chun, Liu Jian-Li, Du Ai-Ling
Department of Cardiology, Affiliated Hospital of Weifang Medical College Weifang City 261031, Shandong Province, China.
Int J Clin Exp Pathol. 2014 Oct 15;7(11):7899-906. eCollection 2014.
Atherogenic or high fat diets were known to induce cardiovascular diseases, and several active compounds were tested to protect/prevent the risk of cardiovascular diseases. We aimed to investigate the cardio protective effect of resveratrol against atherogenic diet fed rats. Male Wistar rats were administered atherogenic diet for 30 days and further continued for 15 days with or with resveratrol in the diet. The serum lipid profile, antioxidant enzyme activity, lipid peroxidation, lipid metabolic proteins and cardiac tissue markers were examined. The histopathology of myocardium and aorta were also examined. The abnormal serum lipid profile found in atherogenic rats was reversed by the administration of resveratrol. Similarly, the enzymatic (catalase, superoxide dismutase, glutathione-peroxidase), non-enzymatic (reduced-glutathione, Vitamin C, E) antioxidants were improved by the resveratrol fed against atherogenic diet. Interestingly, resveratrol activated the lipid metabolic proteins (SIRT1, eNOS and AMPKa), suggesting its protective effect on lipid metabolism. Further analysis on tissue damage revealed that resveratrol had significantly protected the tissue damage and maintains the morphology of cardiac tissue. Altogether, our results suggest that resveratrol played a significant role in the prevention of cardiovascular system against the high fat diet. Emphasising the anti-atherogenic property of resveratrol, we propose resveratrol as a potential compound to be consumed for the healthy life-style.
已知致动脉粥样硬化或高脂肪饮食会诱发心血管疾病，人们对几种活性化合物进行了测试，以保护/预防心血管疾病风险。我们旨在研究白藜芦醇对喂食致动脉粥样硬化饮食大鼠的心脏保护作用。将雄性Wistar大鼠喂食致动脉粥样硬化饮食30天，并在饮食中添加或不添加白藜芦醇的情况下再持续15天。检测血清脂质谱、抗氧化酶活性、脂质过氧化、脂质代谢蛋白和心脏组织标志物。还检查了心肌和主动脉的组织病理学。喂食白藜芦醇可逆转致动脉粥样硬化大鼠中发现的异常血清脂质谱。同样，喂食白藜芦醇对抗致动脉粥样硬化饮食可改善酶促（过氧化氢酶、超氧化物歧化酶、谷胱甘肽过氧化物酶）和非酶促（还原型谷胱甘肽、维生素C、E）抗氧化剂。有趣的是，白藜芦醇激活了脂质代谢蛋白（SIRT1、eNOS和AMPKa），表明其对脂质代谢具有保护作用。对组织损伤的进一步分析表明，白藜芦醇显著保护了组织损伤并维持了心脏组织的形态。总之，我们的结果表明白藜芦醇在预防心血管系统免受高脂肪饮食影响方面发挥了重要作用。强调白藜芦醇的抗动脉粥样硬化特性，我们建议将白藜芦醇作为一种潜在的化合物，用于健康的生活方式。
