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本文引用的文献

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The prognostic effect of perineural invasion in esophageal squamous cell carcinoma.食管鳞状细胞癌中神经周围侵犯的预后影响。
BMC Cancer. 2014 May 5;14:313. doi: 10.1186/1471-2407-14-313.
2
Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention.转录因子 STAT3 作为癌症预防的新分子靶标
Cancers (Basel). 2014 Apr 16;6(2):926-57. doi: 10.3390/cancers6020926.
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The Multifaceted Roles of STAT3 Signaling in the Progression of Prostate Cancer.STAT3 信号在前列腺癌进展中的多方面作用。
Cancers (Basel). 2014 Apr 9;6(2):829-59. doi: 10.3390/cancers6020829.
4
Epstein-Barr Virus encoded LMP1 regulates cyclin D1 promoter activity by nuclear EGFR and STAT3 in CNE1 cells.爱泼斯坦-巴尔病毒编码的LMP1通过细胞核表皮生长因子受体（EGFR）和信号转导子与转录激活子3（STAT3）调控CNE1细胞中细胞周期蛋白D1启动子的活性。
J Exp Clin Cancer Res. 2013 Nov 13;32(1):90. doi: 10.1186/1756-9966-32-90.
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Clinicopathological and prognostic role of MMP-9 in esophageal squamous cell carcinoma: a meta-analysis.MMP-9 在食管鳞状细胞癌中的临床病理和预后作用：一项荟萃分析。
Chin J Cancer Res. 2013 Dec;25(6):637-45. doi: 10.3978/j.issn.1000-9604.2013.11.03.
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Targeting the tumor microenvironment: JAK-STAT3 signaling.靶向肿瘤微环境：JAK-STAT3信号通路
JAKSTAT. 2013 Apr 1;2(2):e23828. doi: 10.4161/jkst.23828.
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Prediagnostic plasma vitamin C and risk of gastric adenocarcinoma and esophageal squamous cell carcinoma in a Chinese population.中文人群中，诊断前血浆维生素 C 与胃腺癌和食管鳞癌风险的关系。
Am J Clin Nutr. 2013 Nov;98(5):1289-97. doi: 10.3945/ajcn.113.061267. Epub 2013 Sep 11.
8
CCND1/CyclinD1 status in metastasizing bladder cancer: a prognosticator and predictor of chemotherapeutic response.CCND1/细胞周期蛋白 D1 状态在转移性膀胱癌中的作用：预测化疗反应的预后因素。
Mod Pathol. 2014 Jan;27(1):87-95. doi: 10.1038/modpathol.2013.125. Epub 2013 Jul 26.
9
An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas.乳腺乳头瘤和乳头状癌中细胞周期蛋白 D1、细胞角蛋白 5/6 和细胞角蛋白 8/18 表达的分析。
Diagn Pathol. 2013 Jan 18;8:8. doi: 10.1186/1746-1596-8-8.
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Combination of meta-analysis and graph clustering to identify prognostic markers of ESCC.Meta 分析与图聚类相结合，鉴定 ESCC 的预后标志物。
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STAT3和细胞周期蛋白D1的双高表达与食管鳞状细胞癌根治性切除术后的不良预后相关。

Dual high expression of STAT3 and cyclinD1 is associated with poor prognosis after curative resection of esophageal squamous cell carcinoma.

作者信息

Li Haiying, Xiao Weiwei, Ma Jiwei, Zhang Yong, Li Ru, Ye Jiecheng, Wang Xiao, Zhong Xueyun, Wang Shaoxiang

机构信息

Department of Pathology, School of Medicine, Jinan University Guangzhou 510632, Guangdong Province, China ; Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, School of Medicine, Jinan University Guangzhou 510632, Guangdong Province, China.

Department of Radiation Oncology, Sun Yat-Sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine Guangzhou, Guangdong, China.

出版信息

Int J Clin Exp Pathol. 2014 Oct 15;7(11):7989-98. eCollection 2014.

PMID:25550842
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4270557/
Abstract

BACKGROUND

Signal transducer of activator of transcription 3 (STAT3) and cyclinD1 are overexpressed in various human cancers, and their overexpression positively correlates to tumor progression and poor prognosis. However, the clinical significance of dual high expression of these two proteins in esophageal squamous cell carcinoma (ESCC) has yet to be determined.

METHODS

The expression of STAT3 and cyclinD1 was analyzed in tissue microarrays containing tumor and adjacent tissue samples from 82 patients who had undergone curative resection for histologically proven ESCC. Kaplan-Meier plots and Cox proportional hazards regression model were used to analyze the prognostic value of STAT3 and cyclinD1 expression.

RESULTS

We discovered that expressions of STAT3 and cyclinD1 in cancer tissues were significantly higher than that in adjacent tissues. High expression of STAT3 and cyclinD1 was associated with malignant behaviors. Moreover, the expression of STAT3 was positively associated with the expression of cyclinD1. High STAT3 or cyclinD1 expression alone was associated with lower overall survival (OS) rates. Furthermore, dual high expression of STAT3 and cyclinD1 expression predict even worse survival outcome in both univariate and multivariate analysis.

CONCLUSION

STAT3 and cyclinD1 correlate with more aggressive tumor behavior in ESCC. When STAT3 and cyclinD1 are considered together, they serve as effective prognostic markers in patients with surgically resected ESCC.

摘要

背景

信号转导子与转录激活子3（STAT3）和细胞周期蛋白D1在多种人类癌症中过表达，它们的过表达与肿瘤进展和不良预后呈正相关。然而，这两种蛋白在食管鳞状细胞癌（ESCC）中双高表达的临床意义尚未确定。

方法

对82例经组织学证实为ESCC并接受根治性切除的患者的肿瘤和癌旁组织样本的组织芯片进行STAT3和细胞周期蛋白D1表达分析。采用Kaplan-Meier生存曲线和Cox比例风险回归模型分析STAT3和细胞周期蛋白D1表达的预后价值。

结果

我们发现癌组织中STAT3和细胞周期蛋白D1的表达显著高于癌旁组织。STAT3和细胞周期蛋白D1的高表达与恶性行为相关。此外，STAT3的表达与细胞周期蛋白D1的表达呈正相关。单独的STAT3或细胞周期蛋白D1高表达与较低的总生存率（OS）相关。此外，在单因素和多因素分析中，STAT3和细胞周期蛋白D1的双高表达预示着更差的生存结果。

结论

STAT3和细胞周期蛋白D1与ESCC中更具侵袭性的肿瘤行为相关。当同时考虑STAT3和细胞周期蛋白D1时，它们可作为手术切除的ESCC患者有效的预后标志物。