Yuan Qiao-ying, Zhang Ling, Xiao Dan, Zhao Kun, Lin Chun, Si Liang-yi
Department of Geriatrics, Southwest Hospital, the Third Military Medical University, Chongqing, PR China.
Department of Out-patient clinic (OPD), Southwest hospital, the Third Military Medical University, Chongqing, PR China.
PLoS One. 2014 Dec 31;9(12):e114794. doi: 10.1371/journal.pone.0114794. eCollection 2014.
Because of the limitations of existing methods and techniques for directly obtaining real-time blood data, no accurate microflow in vivo real-time analysis method exists. To establish a novel technical platform for real-time in vivo detection and to analyze average blood pressure and other blood flow parameters, a small, accurate, flexible, and nontoxic Fabry-Perot fiber sensor was designed. The carotid sheath was implanted through intubation of the rabbit carotid artery (n = 8), and the blood pressure and other detection data were determined directly through the veins. The fiber detection results were compared with test results obtained using color Doppler ultrasound and a physiological pressure sensor recorder. Pairwise comparisons among the blood pressure results obtained using the three methods indicated that real-time blood pressure information obtained through the fiber sensor technique exhibited better correlation than the data obtained with the other techniques. The highest correlation (correlation coefficient of 0.86) was obtained between the fiber sensor and pressure sensor. The blood pressure values were positively related to the total cholesterol level, low-density lipoprotein level, number of red blood cells, and hemoglobin level, with correlation coefficients of 0.033, 0.129, 0.358, and 0.373, respectively. The blood pressure values had no obvious relationship with the number of white blood cells and high-density lipoprotein and had a negative relationship with triglyceride levels, with a correlation coefficient of -0.031. The average ambulatory blood pressure measured by the fiber sensor exhibited a negative correlation with the quantity of blood platelets (correlation coefficient of -0.839, P<0.05). The novel fiber sensor can thus obtain in vivo blood pressure data accurately, stably, and in real time; the sensor can also determine the content and status of the blood flow to some extent. Therefore, the fiber sensor can obtain partially real-time vascular rheology information and may thus enable the early diagnosis of blood rheology disorders and diseases.
由于现有直接获取实时血液数据的方法和技术存在局限性，目前尚无准确的体内微血流实时分析方法。为建立一个用于实时体内检测的新型技术平台，并分析平均血压和其他血流参数，设计了一种小型、精确、灵活且无毒的法布里-珀罗光纤传感器。通过兔颈动脉插管（n = 8）植入颈动脉鞘，直接通过静脉测定血压和其他检测数据。将光纤检测结果与使用彩色多普勒超声和生理压力传感器记录仪获得的测试结果进行比较。对三种方法获得的血压结果进行两两比较表明，通过光纤传感器技术获得的实时血压信息比其他技术获得的数据具有更好的相关性。光纤传感器与压力传感器之间的相关性最高（相关系数为0.86）。血压值与总胆固醇水平、低密度脂蛋白水平、红细胞数量和血红蛋白水平呈正相关，相关系数分别为0.033、0.129、0.358和0.373。血压值与白细胞数量和高密度脂蛋白无明显关系，与甘油三酯水平呈负相关，相关系数为-0.031。光纤传感器测量的平均动态血压与血小板数量呈负相关（相关系数为-0.839，P<0.05）。因此，这种新型光纤传感器能够准确、稳定且实时地获取体内血压数据；该传感器还能在一定程度上确定血流的含量和状态。所以，光纤传感器能够获取部分实时血管流变学信息，从而可能实现血液流变学紊乱和疾病的早期诊断。
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