Department of Pediatric Surgery, Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Ankara, Turkey.
Turk J Med Sci. 2014;44(6):1103-7. doi: 10.3906/sag-1312-3.
BACKGROUND/AIM: To compare estrogen and betamethasone in the topical treatment of labial adhesions in prepubertal girls.
In this retrospective study, we evaluated 39 girls with labial adhesions covering at least 50% of the vaginal opening. Of the total patients, 20 were treated with a topical estrogen preparation, while the remaining 19 patients were treated with a combination of betamethasone cream and petroleum ointment (Vaseline) for 3 to 9 weeks.
Sixteen of 20 (80%) patients in the estrogen treatment group were treated successfully with topical estrogen cream only, and 17 of 19 (89.4%) patients in the second group were treated successfully with a combination of betamethasone cream and petroleum ointment. Two patients (2/20) in the estrogen treatment group underwent a surgical procedure for the manual separation of the labial adhesion. One patient (1/19) treated with betamethasone cream and petroleum ointment required a manual separation procedure. We observed a side effect of labial enlargement in 2 patients (10%) who were treated with estrogen only, while the only side effect of the betamethasone treatment was local irritation, which occurred in a single patient (5.2%). In addition, the success rate of the betamethasone treatment exceeded that of the topical estrogen (89.4% and 80%, respectively).
Betamethasone cream with petroleum ointment is a safe and effective primary therapy for prepubertal labial adhesions.
背景/目的：比较雌激素和倍他米松在治疗青春期前女童阴唇粘连中的局部应用。
在这项回顾性研究中，我们评估了 39 名阴唇粘连覆盖阴道开口至少 50%的女孩。在所有患者中，20 名患者接受雌激素局部制剂治疗，而其余 19 名患者接受倍他米松乳膏和石油软膏（凡士林）联合治疗 3 至 9 周。
雌激素治疗组 20 名患者中的 16 名（80%）仅用雌激素乳膏成功治疗，倍他米松乳膏和石油软膏治疗组 19 名患者中的 17 名（89.4%）成功治疗。雌激素治疗组中有 2 名患者（2/20）需要进行阴唇粘连的手动分离手术。接受倍他米松乳膏和石油软膏治疗的 1 名患者（1/19）需要进行手动分离手术。我们观察到仅用雌激素治疗的 2 名患者（10%）出现阴唇增大的副作用，而倍他米松治疗的唯一副作用是局部刺激，仅发生在 1 名患者（5.2%）中。此外，倍他米松治疗的成功率高于雌激素治疗（分别为 89.4%和 80%）。
倍他米松乳膏联合石油软膏是治疗青春期前阴唇粘连的一种安全有效的一线治疗方法。
