Ding Baixing, Hu Fupin, Yang Yang, Guo Qinglan, Huang Jinwei, Wang Minggui
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China.
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China
J Clin Microbiol. 2015 Mar;53(3):1031-3. doi: 10.1128/JCM.03623-14. Epub 2014 Dec 31.
Carbapenem-resistant Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Acinetobacter baumannii were isolated from a single patient, each producing different carbapenemases (NDM-1, KPC-2, IMP, and OXA-23, respectively). The NDM-1-producing E. coli strain was preceded by a clonally related carbapenem-susceptible strain a month earlier, suggesting in vivo acquisition of blaNDM-1.
耐碳青霉烯类的大肠埃希菌、肺炎克雷伯菌、产气肠杆菌和鲍曼不动杆菌从一名患者体内分离得到,它们分别产生不同的碳青霉烯酶(分别为NDM-1、KPC-2、IMP和OXA-23)。一个月前,该产NDM-1的大肠埃希菌菌株之前是一株克隆相关的对碳青霉烯类敏感的菌株,这表明blaNDM-1是在体内获得的。