金鱼草中转座子诱导的 nivea 基因座缺失的分子分析。
Molecular analysis of a transposon-induced deletion of the nivea locus in Antirrhinum majus.
作者信息
Lister C, Martin C
机构信息
John Innes Institute, Norwich, England.
出版信息
Genetics. 1989 Oct;123(2):417-25. doi: 10.1093/genetics/123.2.417.
Abstract
The transposable element Tam3 of Antirrhinum majus is capable of causing large-scale chromosomal restructuring. It induced a large deletion at the nivea locus, to produce the allele niv-:529. The deletion removed the entire nivea coding region while the element remains intact with the potential to induce further rearrangements. Genetic experiments showed that the endpoint of the deletion (called x) is closely linked to nivea. The DNA sequences of niv-:529, a genomic excision of Tam3 from niv-:529, and the original genomic position of x have been determined. These data suggest that the deletion could have resulted from an abortive transposition or through breakage and religation.
摘要
金鱼草的转座元件Tam3能够引起大规模的染色体重组。它在nivea位点诱导了一个大的缺失，产生了等位基因niv-:529。该缺失去除了整个nivea编码区，而元件保持完整，仍有可能诱导进一步的重排。遗传实验表明，缺失的端点（称为x）与nivea紧密连锁。已经确定了niv-:529的DNA序列、Tam3从niv-:529的基因组切除以及x的原始基因组位置。这些数据表明，该缺失可能是由于失败的转座或通过断裂和重新连接导致的。
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