Kwon Hee Jin, Yoo Kwai Han, Kim In Young, Lee Seulkee, Jang Hye Ryoun, Kwon Ghee Young
Department of Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea.
Division of Nephrology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J Korean Med Sci. 2015 Jan;30(1):110-4. doi: 10.3346/jkms.2015.30.1.110. Epub 2014 Dec 23.
Megalocytic interstitial nephritis is a rare form of kidney disease caused by chronic inflammation. We report a case of megalocytic interstitial nephritis occurring in a 45-yrold woman who presented with oliguric acute kidney injury and acute pyelonephritis accompanied by Escherichia coli bacteremia. Her renal function was not recovered despite adequate duration of susceptible antibiotic treatment, accompanied by negative conversion of bacteremia and bacteriuria. Kidney biopsy revealed an infiltration of numerous histiocytes without Michaelis-Gutmann bodies. The patient's renal function was markedly improved after short-term treatment with high-dose steroid.
巨细胞性间质性肾炎是一种由慢性炎症引起的罕见肾病形式。我们报告一例发生在一名45岁女性的巨细胞性间质性肾炎病例，该患者表现为少尿性急性肾损伤和急性肾盂肾炎，并伴有大肠杆菌菌血症。尽管接受了足够疗程的敏感抗生素治疗，其肾功能仍未恢复，同时菌血症和菌尿症转阴。肾活检显示有大量组织细胞浸润，但无迈克尔is-Gutmann小体。患者经大剂量类固醇短期治疗后肾功能明显改善。
