非裔美国女性和白种女性在胰岛素抵抗和内脏肥胖方面的种族差异与载有载脂蛋白 CIII 的载脂蛋白 AI 和载脂蛋白 B 脂蛋白的差异有关。
Racial differences between African-American and white women in insulin resistance and visceral adiposity are associated with differences in apoCIII containing apoAI and apoB lipoproteins.
机构信息
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 1, Room 201, Boston, MA 02115 USA.
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Building 1, Room 201, Boston, MA 02115 USA ; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA.
出版信息
Nutr Metab (Lond). 2014 Dec 17;11(1):56. doi: 10.1186/1743-7075-11-56. eCollection 2014.
BACKGROUND
African-Americans have higher HDL, less visceral adipose tissue (VAT) and lower triglyceride (TG) and apoCIII concentrations than whites, despite being more insulin-resistant. We studied in African-American and white women the influences of insulin resistance and VAT on the apoAI concentrations of two HDL subspecies, one that contains apoCIII that is associated with increased risk of coronary heart disease (CHD) and one that does not have apoCIII that is associated with decreased CHD; and on the apoCIII concentrations of HDL and of the apoB lipoproteins.
METHODS
The participants were 32 women (14 African-Americans, 18 white) of similar age (39 ± 12 vs. 42 ± 11y). Mean BMI was 34 kg/m(2) in the African-Americans compared to 30 in the whites. A standard diet (33% fat, 52% carbohydrate, 15% protein) was provided for 7 days followed by a test meal (40% fat, 40% carbohydrate, 20% protein) on Day 8. Insulin sensitivity index (SI) was calculated from the minimal model.
RESULTS
After controlling for SI, African-Americans have a higher mean apoAI level in HDL with apoCIII compared with whites (12.9 ± 2.8 and 10.9 ± 2.9 mg/dL, respectively, P = 0.05). SI was associated with higher apoAI in HDL with apoCIII, whereas VAT was not associated with this HDL subspecies. This pattern of results was reversed for apoCIII concentrations in apoB lipoproteins. After adjusting for SI, African-Americans had lower apoCIII in apoB lipoproteins. SI was associated with lower apoCIII in total apoB lipoproteins, whereas VAT was associated with higher apoCIII in all the apoB lipoproteins. Additional adjustment for VAT tended to reduce the difference in apoCIII between the groups.
CONCLUSIONS
African-American women have a higher HDL with apoCIII level than whites when controlled for insulin sensitivity. African-Americans have lower insulin sensitivity. Insulin sensitivity is associated with higher levels of HDL with apoCIII. ApoCIII levels in VLDL are lower in African-American women than whites, also affected by insulin sensitivity which is associated with low apoCIII in VLDL. VAT has a strong association with apoCIII in apoB lipoproteins but not with apoAI in HDL with apoCIII.
TRIAL REGISTRATION
ClinicalTrials.gov Identifier: NCT00484861.
背景
尽管非裔美国人的胰岛素抵抗程度更高，但他们的高密度脂蛋白 (HDL) 水平更高，内脏脂肪组织 (VAT) 更少，甘油三酯 (TG) 和载脂蛋白 CIII (apoCIII) 浓度更低。我们在非裔美国人和白人女性中研究了胰岛素抵抗和 VAT 对两种 HDL 亚类的 apoAI 浓度的影响，一种含有与冠心病 (CHD) 风险增加相关的 apoCIII，另一种则不含有与 CHD 风险降低相关的 apoCIII；还研究了 HDL 和 apoB 脂蛋白中的 apoCIII 浓度。
方法
参与者为 32 名女性（14 名非裔美国人，18 名白人），年龄相仿（39 ± 12 岁 vs. 42 ± 11 岁）。非裔美国人的平均 BMI 为 34 kg/m²，而白人为 30 kg/m²。第 8 天，在提供 7 天标准饮食（33%脂肪、52%碳水化合物、15%蛋白质）后，进行测试餐（40%脂肪、40%碳水化合物、20%蛋白质）。胰岛素敏感指数（SI）根据最小模型计算得出。
结果
在控制 SI 后，非裔美国人的载有 apoCIII 的 HDL 中的 apoAI 水平高于白人（分别为 12.9 ± 2.8 和 10.9 ± 2.9 mg/dL，P = 0.05）。SI 与载有 apoCIII 的 HDL 中的 apoAI 水平升高相关，而 VAT 与该 HDL 亚类无关。apoB 脂蛋白中的 apoCIII 浓度则呈现出相反的结果。在调整 SI 后，非裔美国人的 apoB 脂蛋白中的 apoCIII 水平较低。SI 与总 apoB 脂蛋白中的 apoCIII 水平降低相关，而 VAT 与所有 apoB 脂蛋白中的 apoCIII 水平升高相关。进一步调整 VAT 会降低组间 apoCIII 的差异。
结论
在控制胰岛素敏感性后，非裔美国女性的载有 apoCIII 的 HDL 水平高于白人。非裔美国人的胰岛素敏感性较低。胰岛素敏感性与载有 apoCIII 的 HDL 水平升高相关。非裔美国女性的 VLDL 中的 apoCIII 水平低于白人，这也受到胰岛素敏感性的影响，而胰岛素敏感性与 VLDL 中的 apoCIII 水平降低相关。VAT 与 apoB 脂蛋白中的 apoCIII 具有很强的关联，但与载有 apoCIII 的 HDL 中的 apoAI 无关。
临床试验注册
ClinicalTrials.gov 标识符：NCT00484861。
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