Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.
J Lipid Res. 2012 Dec;53(12):2767-72. doi: 10.1194/jlr.P030593. Epub 2012 Oct 9.
Type 2 diabetes mellitus (T2DM) is associated with increased plasma triglyceride (TG) concentrations, but African Americans (AA) have lower plasma TG than Caucasians (CC). We evaluated the hypothesis that obese AA women have lower plasma TG than obese CC women do because of differences in lipid kinetics. Eleven AA and 11 CC obese women with T2DM, matched on body mass index (BMI) (AA = 37 ± 1, CC = 37 ± 1 kg/m(2)), age, duration of diabetes, percentage body fat, and insulin sensitivity (S(I), determined by an intravenous glucose tolerance test), were studied. Plasma TG concentration (AA = 1.14 ± 0.11, CC = 1.88 ± 0.18 mmol/l), FFA rate of appearance (R(a)) into plasma (AA = 419 ± 27, CC = 503 ± 31 µmol·min(-1)), and total VLDL-TG secretion rate (AA = 18 ± 2, CC = 29 ± 4 µmol·min(-1)) were lower in AA than CC women (all P < 0.05). In contrast, plasma total apolipoprotein (apo)B-100 concentration (AA = 1,542 ± 179, CC = 1,620 ± 118 nmol/l) and VLDL-apoB-100 secretion rate (AA = 1.3 ± 0.1, CC = 1.3 ± 0.1 nmol·min(-1)) were similar in both groups, so the molar ratio of VLDL-TG secretion rate to VLDL-apoB-100 secretion rate was lower in AA women than in CC women. VLDL-TG concentration was lower in AA women due to lower total VLDL-TG secretion rate. However, the VLDL-apoB-100 secretion rate was the same in both groups, demonstrating that AA women secrete smaller VLDL particles containing less TG than do CC women.
2 型糖尿病（T2DM）与血浆甘油三酯（TG）浓度升高有关，但非裔美国人（AA）的血浆 TG 低于白种人（CC）。我们评估了这样一个假设，即肥胖的 AA 女性的血浆 TG 低于肥胖的 CC 女性，这是由于脂质动力学的差异。11 名患有 T2DM 的肥胖 AA 女性和 11 名肥胖 CC 女性，按体重指数（BMI）（AA = 37 ± 1，CC = 37 ± 1 kg/m(2)）、年龄、糖尿病持续时间、体脂百分比和胰岛素敏感性（S(I)，通过静脉葡萄糖耐量试验确定）进行匹配。AA 女性的血浆 TG 浓度（AA = 1.14 ± 0.11，CC = 1.88 ± 0.18 mmol/l）、FFA 向血浆中的出现率（R(a)）（AA = 419 ± 27，CC = 503 ± 31 µmol·min(-1)）和 VLDL-TG 分泌率（AA = 18 ± 2，CC = 29 ± 4 µmol·min(-1)）均低于 CC 女性（均 P < 0.05）。相比之下，AA 女性的血浆总载脂蛋白（apo）B-100 浓度（AA = 1,542 ± 179，CC = 1,620 ± 118 nmol/l）和 VLDL-apoB-100 分泌率（AA = 1.3 ± 0.1，CC = 1.3 ± 0.1 nmol·min(-1)）在两组之间相似，因此 AA 女性的 VLDL-TG 分泌率与 VLDL-apoB-100 分泌率的摩尔比低于 CC 女性。AA 女性的 VLDL-TG 浓度较低是由于总 VLDL-TG 分泌率较低。然而，两组的 VLDL-apoB-100 分泌率相同，表明 AA 女性分泌的含有较少 TG 的较小 VLDL 颗粒多于 CC 女性。
