Shinkai T, Saijo N, Eguchi K, Sasaki Y, Tamura T, Fujiwara Y, Kojima A, Nakagawa K, Minato K, Nakajima T
Department of Internal Medicine, National Cancer Center Hospital, Tokyo.
Jpn J Cancer Res. 1989 Aug;80(8):783-6. doi: 10.1111/j.1349-7006.1989.tb01715.x.
The frequencies of sister chromatid exchanges (SCE) in the peripheral lymphocytes of patients with lung cancer before and after initial chemotherapy were serially measured and the correlation between SCE frequencies and bone marrow toxicity was evaluated. The addition of mitomycin C to vindesine plus cisplatin increased SCE frequencies significantly in patients with non-small cell lung cancer. A significant increase in frequencies of SCE was observed in patients treated with cyclophosphamide plus adriamycin plus vincristine as compared with those treated with cisplatin plus etoposide in small cell lung cancer. A significant inverse correlation was observed between SCE frequencies in the peripheral lymphocytes 7 days after treatment (x) and the nadir value/pretreatment value of platelets (y)(r = -0.685, P = 0.0007, y = 0.842-0.022x). The relation between SCE frequency and leukopenia showed the same trend as thrombocytopenia, but the correlation was not statistically significant (r = -0.444, P = 0.057). SCE assay may have potential clinical use for the prediction of chemotherapy-induced thrombocytopenia.
对肺癌患者初次化疗前后外周血淋巴细胞中姐妹染色单体交换（SCE）的频率进行了连续测定，并评估了SCE频率与骨髓毒性之间的相关性。在长春地辛加顺铂的基础上加用丝裂霉素C可显著增加非小细胞肺癌患者的SCE频率。与接受顺铂加依托泊苷治疗的小细胞肺癌患者相比，接受环磷酰胺加多柔比星加长春新碱治疗的患者SCE频率显著增加。治疗7天后外周血淋巴细胞中的SCE频率（x）与血小板的最低点值/预处理值（y）之间存在显著负相关（r = -0.685，P = 0.0007，y = 0.842 - 0.022x）。SCE频率与白细胞减少之间的关系与血小板减少呈相同趋势，但相关性无统计学意义（r = -0.444，P = 0.057）。SCE检测可能在预测化疗引起的血小板减少方面具有潜在的临床应用价值。
