多囊卵巢综合征患者子宫内膜中细胞粘附分子与雌激素受体表达的系统评价

Systematic review of cell adhesion molecules and estrogen receptor expression in the endometrium of patients with polycystic ovary syndrome.

作者信息

Baracat Maria Cândida P, Serafini Paulo C, Simões Ricardo Dos S, Maciel Gustavo A R, Soares José M, Baracat Edmund C

机构信息

Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

出版信息

Int J Gynaecol Obstet. 2015 Apr;129(1):1-4. doi: 10.1016/j.ijgo.2014.10.022. Epub 2014 Dec 18.

DOI:10.1016/j.ijgo.2014.10.022

PMID:25554522

Abstract

BACKGROUND

Infertility associated with polycystic ovary syndrome (PCOS) could be related to many mechanisms including endometrial factors.

OBJECTIVES

To review cell adhesion molecule and estrogen receptor expression in the endometrium.

SEARCH STRATEGY

A systematic review was performed of the Medline and Cochrane databases for papers published in any language between 2004 and 2014. The search term was "'polycystic ovary syndrome' OR 'Stein Leventhal syndrome' OR 'anovulation' AND 'endometrium' OR 'endometria.'"

SELECTION CRITERIA

Research studies on endometrial cell adhesion molecules and estrogen receptor expression among women with PCOS diagnosed according to the Rotterdam criteria were included.

DATA COLLECTION AND ANALYSIS

Data were extracted from identified studies and the quality of assessment was analyzed.

MAIN RESULTS

Six studies were included. Data were controversial with respect to MUC1 and αVβ3 integrin expression with significantly higher and lower levels, respectively, in women with PCOS. Estrogen receptor expression was enhanced among patients with PCOS as compared with healthy women.

CONCLUSIONS

Endometrial factors influence embryo receptivity as indicated by the molecular mediators identified in the studies, including cell adhesion molecules and the estrogen receptor.

摘要