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多囊卵巢综合征患者子宫内膜中细胞粘附分子与雌激素受体表达的系统评价

Systematic review of cell adhesion molecules and estrogen receptor expression in the endometrium of patients with polycystic ovary syndrome.

作者信息

Baracat Maria Cândida P, Serafini Paulo C, Simões Ricardo Dos S, Maciel Gustavo A R, Soares José M, Baracat Edmund C

机构信息

Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia do Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

出版信息

Int J Gynaecol Obstet. 2015 Apr;129(1):1-4. doi: 10.1016/j.ijgo.2014.10.022. Epub 2014 Dec 18.

DOI:10.1016/j.ijgo.2014.10.022
PMID:25554522
Abstract

BACKGROUND

Infertility associated with polycystic ovary syndrome (PCOS) could be related to many mechanisms including endometrial factors.

OBJECTIVES

To review cell adhesion molecule and estrogen receptor expression in the endometrium.

SEARCH STRATEGY

A systematic review was performed of the Medline and Cochrane databases for papers published in any language between 2004 and 2014. The search term was "'polycystic ovary syndrome' OR 'Stein Leventhal syndrome' OR 'anovulation' AND 'endometrium' OR 'endometria.'"

SELECTION CRITERIA

Research studies on endometrial cell adhesion molecules and estrogen receptor expression among women with PCOS diagnosed according to the Rotterdam criteria were included.

DATA COLLECTION AND ANALYSIS

Data were extracted from identified studies and the quality of assessment was analyzed.

MAIN RESULTS

Six studies were included. Data were controversial with respect to MUC1 and αVβ3 integrin expression with significantly higher and lower levels, respectively, in women with PCOS. Estrogen receptor expression was enhanced among patients with PCOS as compared with healthy women.

CONCLUSIONS

Endometrial factors influence embryo receptivity as indicated by the molecular mediators identified in the studies, including cell adhesion molecules and the estrogen receptor.

摘要

背景

多囊卵巢综合征（PCOS）相关的不孕症可能与多种机制有关，包括子宫内膜因素。

目的

综述子宫内膜中细胞黏附分子和雌激素受体的表达。

检索策略

对Medline和Cochrane数据库进行系统综述，以查找2004年至2014年间以任何语言发表的论文。检索词为“'多囊卵巢综合征' 或 '斯坦因-莱文塔尔综合征' 或 '无排卵' 以及 '子宫内膜' 或 '子宫内膜'”。

选择标准

纳入根据鹿特丹标准诊断为PCOS的女性中关于子宫内膜细胞黏附分子和雌激素受体表达的研究。

数据收集与分析

从已识别的研究中提取数据，并对评估质量进行分析。

主要结果

纳入了六项研究。关于MUC1和αVβ3整合素的表达，数据存在争议，PCOS女性中这两种分子的表达水平分别显著升高和降低。与健康女性相比，PCOS患者的雌激素受体表达增强。

结论

研究中确定的分子介质（包括细胞黏附分子和雌激素受体）表明，子宫内膜因素会影响胚胎着床能力。

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