Albert Verena, Hall Michael N
Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
Biozentrum, University of Basel, CH-4056 Basel, Switzerland.
Curr Opin Cell Biol. 2015 Apr;33:55-66. doi: 10.1016/j.ceb.2014.12.001. Epub 2014 Dec 31.
Mammalian TOR (mTOR) signaling controls growth, metabolism and energy homeostasis in a cell autonomous manner. Recent findings indicate that mTOR signaling in one tissue can also affect other organs thereby affecting whole body metabolism and energy homeostasis in a non-cell autonomous manner. It is thus not surprising that mTOR signaling mediates aging and is often deregulated in metabolic disorders, such as obesity, diabetes and cancer. This review discusses the regulation of cellular and whole body energy metabolism by mTOR, with particular focus on the non-cell autonomous function of mTOR.
哺乳动物雷帕霉素靶蛋白（mTOR）信号通路以细胞自主的方式控制细胞的生长、代谢和能量稳态。最近的研究结果表明，一个组织中的mTOR信号通路也可以影响其他器官，从而以非细胞自主的方式影响全身代谢和能量稳态。因此，mTOR信号通路介导衰老且在代谢紊乱（如肥胖、糖尿病和癌症）中常常失调也就不足为奇了。本综述讨论了mTOR对细胞和全身能量代谢的调节，特别关注mTOR的非细胞自主功能。
Zotero 插件