Yen Rachel Lai Siaw, Telisinghe Pemasari Upali, Cunningham Anne, Abdullah Muhd Syafiq, Chong Chee Fui, Chong Vui Heng
PAPRSB IHS Universiti Brunei Darussalam, Brunei Darussalam E-mail :
Asian Pac J Cancer Prev. 2014;15(23):10489-93. doi: 10.7314/apjcp.2014.15.23.10489.
Gastric cancer is the second most common gastrointestinal cancer and is largely attributed to Helicobacter pylori (H. pylori) infection. In addition, studies have also shown association with Epstein-Barr virus (EBV) in 10% of gastric cancers. This study assessed the characteristics of EBV associated gastric cancers (EBVaGC) in Brunei Darussalam.
This study included gastric cancers diagnosed between 2008 and 2012, registered with the Department of Pathology RIPAS Hospital, Brunei Darussalam. Clinical case notes were systematically reviewed. Histology specimens were all stained for EBV and also assessed for intestinal metaplasia and H. pylori.
There were a total of 81 patients (54 male and 27 females) with a mean age of 65.8±14.8 years included in the study. Intestinal metaplasia and active H. pylori infection were detected in 40.7% and 30.9% respectively. A majority of the tumors were proximally located (55.6%), most poorly differentiated (well differentiated 16%, moderately differentiated 30.9% and poorly differentiated 53.1%) and the stages at diagnosis were; stage I (44.4%), stage II (23.5%), stage III (8.6%) and stage IV (23.5%). EBV positivity (EBVaGC) was seen in 30.9%. Between EBVaGC and EBV negative gastric cancers, there were no significant differences (age, gender, ethnic group, presence of Intestinal metaplasia, tumor locations, stages of disease and degree of tumor differentiation).
This study showed that a third of gastric cancers in Brunei Darussalam were positive for EBV, higher than what have been reported in the literature. However, there were no significant differences between EBVaGC and EBV negative gastric cancers. This suggests that the role of EBV in gastric cancer may be mostly incidental rather than any causal relation. However, further studies are required.
胃癌是第二常见的胃肠道癌症，主要归因于幽门螺杆菌（H. pylori）感染。此外，研究还表明，10%的胃癌与爱泼斯坦-巴尔病毒（EBV）有关。本研究评估了文莱达鲁萨兰国EBV相关胃癌（EBVaGC）的特征。
本研究纳入了2008年至2012年间在文莱达鲁萨兰国RIPAS医院病理科登记诊断的胃癌患者。系统回顾临床病例记录。组织学标本均进行EBV染色，并评估肠化生和幽门螺杆菌情况。
本研究共纳入81例患者（54例男性和27例女性），平均年龄65.8±14.8岁。分别在40.7%和30.9%的患者中检测到肠化生和活动性幽门螺杆菌感染。大多数肿瘤位于近端（55.6%），分化程度最差（高分化16%，中分化30.9%，低分化53.1%），诊断时的分期为：I期（44.4%），II期（23.5%），III期（8.6%）和IV期（23.5%）。EBV阳性（EBVaGC）见于30.9%的患者。在EBVaGC和EBV阴性胃癌之间，无显著差异（年龄、性别、种族、肠化生的存在、肿瘤位置、疾病分期和肿瘤分化程度）。
本研究表明，文莱达鲁萨兰国三分之一的胃癌EBV呈阳性，高于文献报道。然而，EBVaGC和EBV阴性胃癌之间无显著差异。这表明EBV在胃癌中的作用可能主要是偶然的，而非因果关系。然而，仍需要进一步研究。
