Department of Pathology, Daejeon Eulji University Hospital, Eulji University School of Medicine, Daejeon 35233, Korea.
Department of Internal Medicine, Daejeon Eulji University Hospital, Eulji University School of Medicine, Daejeon 35233, Korea.
Medicina (Kaunas). 2020 Jul 13;56(7):345. doi: 10.3390/medicina56070345.
: The present study aims to elucidate the clinicopathologic significance of Epstein-Barr virus (EBV) infection in gastric carcinomas (GCs) through a meta-analysis. : Sixty-one eligible studies were included in the present meta-analysis. The included patients, with and without EBV infection, were 2063 and 17,684, respectively. We investigated the clinicopathologic characteristics and various biomarkers, including programmed death-ligand 1 (PD-L1) expression and tumor-infiltrating lymphocytes (TILs). : The estimated EBV-infected rate of GCs was 0.113 (95% confidence interval (CI): 0.088-0.143). The EBV infection rates in GC cells were 0.138 (95% CI: 0.096-0.194), 0.103 (95% CI: 0.077-0.137), 0.080 (95% CI: 0.061-0.106), and 0.042 (95% CI: 0.016-0.106) in the population of Asia, America, Europe, and Africa, respectively. There was a significant difference between EBV-infected and noninfected GCs in the male: female ratio, but not other clinicopathological characteristics. EBV infection rates were higher in GC with lymphoid stroma (0.573, 95% CI: 0.428-0.706) than other histologic types of GCs. There were significant differences in high AT-rich interactive domain-containing protein 1A (ARID1A) and PD-L1 expressions, and high CD8+ TILs between EBV-infected and noninfected GCs. : Our results showed that EBV infection of GCs was frequently found in male patients and GCs with lymphoid stroma. EBV infection was significantly correlated with ARID1A and PD-L1 expressions and CD8+ TILs in GCs.
本研究通过荟萃分析旨在阐明 EBV 感染在胃癌（GC）中的临床病理意义。
本荟萃分析纳入了 61 项符合条件的研究。纳入的 EBV 感染和未感染患者分别为 2063 例和 17684 例。我们研究了临床病理特征和各种生物标志物，包括程序性死亡配体 1（PD-L1）表达和肿瘤浸润淋巴细胞（TILs）。
GC 的 EBV 感染率估计为 0.113（95%置信区间[CI]：0.088-0.143）。GC 细胞中的 EBV 感染率分别为 0.138（95%CI：0.096-0.194）、0.103（95%CI：0.077-0.137）、0.080（95%CI：0.061-0.106）和 0.042（95%CI：0.016-0.106）在亚洲、美洲、欧洲和非洲人群中。在男性与女性比例方面，EBV 感染与非感染 GC 之间存在显著差异，但其他临床病理特征无差异。在富含 AT 的交互域蛋白 1A（ARID1A）和 PD-L1 表达以及 CD8+TIL 方面，EBV 感染的 GC 与其他 GC 组织学类型存在显著差异。
我们的结果表明，GC 中的 EBV 感染在男性患者和富含淋巴间质的 GC 中更为常见。EBV 感染与 GC 中的 ARID1A 和 PD-L1 表达以及 CD8+TIL 显著相关。
