Lee Sang Jin, Heo Dong Nyoung, Park Ji Sun, Kwon Seong Keun, Lee Jin Ho, Lee Jun Hee, Kim Wan Doo, Kwon Il Keun, Park Su A
Department of Nature-Inspired Nanoconvergence Systems, Korea Institute of Machinery and Materials, 156 Gajeongbuk-ro, Yuseong-gu, Daejeon 304-343, Republic of Korea.
Phys Chem Chem Phys. 2015 Feb 7;17(5):2996-9. doi: 10.1039/c4cp04801f. Epub 2015 Jan 5.
The last decade has seen artificial blood vessels composed of natural polymer nanofibers grafted into human bodies to facilitate the recovery of damaged blood vessels. However, electrospun nanofibers (ENs) of biocompatible materials such as chitosan (CTS) suffer from poor mechanical properties. This study describes the design and fabrication of artificial blood vessels composed of a blend of CTS and PCL ENs and coated with PCL strands using rapid prototyping technology. The resulting tubular vessels exhibited excellent mechanical properties and showed that this process may be useful for vascular reconstruction.
在过去十年中,由天然聚合物纳米纤维组成的人造血管已被移植到人体中,以促进受损血管的恢复。然而,壳聚糖(CTS)等生物相容性材料的电纺纳米纤维(ENs)的机械性能较差。本研究描述了使用快速成型技术设计和制造由CTS和PCL ENs混合物组成并涂覆有PCL股线的人造血管。所得的管状血管表现出优异的机械性能,并表明该过程可能对血管重建有用。